NCT03800277 (Phenulin) is a NA clinical trial of Cranberry in Endotoxemia, sponsored by Laval University.

Who is sponsoring NCT03800277?

NCT03800277 is sponsored by Laval University.

What drugs are being tested in NCT03800277?

Interventions in NCT03800277: Cranberry, Agaves, Placebo.

What condition does NCT03800277 study?

NCT03800277 studies Endotoxemia, Metabolic Syndrome, Glucose Metabolism Disorders, Insulin Resistance.

Is NCT03800277 still recruiting?

NCT03800277 is currently completed. Last updated 21 March 2023.

Last reviewed 2023-03-21 · How we verify

NCT03800277: Phenulin

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health

Completed NA Last updated 21 March 2023

What this trial tests

NA trial testing Cranberry in Endotoxemia in 122 participants. Completed in 31 December 2021.

Timeline

5 November 2018

Primary endpoint
31 December 2020

31 December 2021

Quick facts

Lead sponsor	Laval University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	122
Start date	5 November 2018
Primary completion	31 December 2020
Estimated completion	31 December 2021
Sites	1 location across Canada

Drugs / interventions tested

Cranberry — full drug profile →
Agaves
Placebo

Conditions studied

Endotoxemia — all drugs for Endotoxemia →
Metabolic Syndrome — all drugs for Metabolic Syndrome →
Glucose Metabolism Disorders — all drugs for Glucose Metabolism Disorders →
Insulin Resistance — all drugs for Insulin Resistance →

Sponsor

Laval University

Who can join

Adults 18 to 70, any sex, with Endotoxemia or Metabolic Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity and associated metabolic health disorders. The gut microbiota compositions plays a decisive role in glucose metabolism and the chronic inflammatory state associated with insulin resistance. Consuming prebiotic rich diet, including polyphenol and inulin rich food could help modulate favorably the gut microbiota which could lead to a reduction of endotoxemia and beneficial metabolic health effects.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome.
Redondo-Castillejo R, Garcimartín A, Hernández-Martín M, López-Oliva ME, et al · · 2023 · cited 19× · PMID 36982444 · DOI 10.3390/ijms24065369

Verify or expand the search:

Other trials of Cranberry

Trials testing the same drug.

NCT05260554 — Effect of Cranberry Extract on the Urinary System · completed
NCT04597554 — Cranberry Supplementation, Viral Defense, Antibody Response to the Flu Shot · NA · completed
NCT04377919 — Effects of Cranberry Supplementation on Chronic Kidney Disease Patients. · NA · completed

Other recruiting trials for Endotoxemia

Currently open trials in the same condition.

NCT05318183 — Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components · NA · active not recruiting
NCT03901807 — Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study · NA · active not recruiting

Other Laval University trials

Trials by the same sponsor.

NCT07491887 — Identification of Objective Metabolomics-based Biomarkers of Yogurt Consumption · NA · not yet recruiting
NCT07366827 — Effectiveness of Motorised Lumbar Support for Non-specific Low Back Pain · NA · not yet recruiting
NCT07317973 — A Study About Patient Decision Aids Designed to Help Parents and Guardians in Canada Make Evidence-informed, Values-cong · NA · not yet recruiting
NCT07293312 — Optimizing the Use of Virtual Reality in Rehabilitation for Individuals With Persistent Shoulder Pain · NA · not yet recruiting
NCT07201870 — Digital Preparation for Bariatric Surgery: Feasability Pilot Trial · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03800277 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Laval University
Last refreshed: 21 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03800277.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing