NCT03796117

Pulsed Current Versus Russian Current Effects in Healthy Young Subjects.

Completed NA Last updated 10 June 2021

What this trial tests

NA trial testing Pulsed current in Healthy Young in 30 participants. Completed in 30 August 2019.

Timeline

8 January 2019

Primary endpoint
30 June 2019

30 August 2019

Quick facts

Lead sponsor	Federal University of Rio Grande do Sul
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	other
Enrollment	30
Start date	8 January 2019
Primary completion	30 June 2019
Estimated completion	30 August 2019
Sites	1 location across Brazil

Drugs / interventions tested

• Pulsed current
• Russian Current

Conditions studied

• Healthy Young — all drugs for Healthy Young →
• Electric Stimulation Therapy — all drugs for Electric Stimulation Therapy →

Sponsor

Federal University of Rio Grande do Sul

Who can join

Adults 18 to 35, male only, with Healthy Young or Electric Stimulation Therapy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Low frequency pulsed current (PC) and medium frequency alternating current (Russian current - RC, 2.5 kHz) have been largely studied due to their clinical use. However, it is not clear which current is the most efficient due to the existente literature conflicts.Therefore, the purpose of this study is to compare the neuromuscular efficiency, evoked torque, current intensity, fatigability and level of discomfort between the PC and the RC in healthy young. The current types will be tested in the same participant by the intervention sequences randomization. On the first, second, third and fourth days, the maximum voluntary isometric contraction (MVIC), the current intensity level, discomfort level, evoked torque, and clinical and neuromuscular efficiency of each current will be evaluated. Anthropometric measurements will also be assessed on the first day. In addition, the current intensity required to produce a torque level of 20% of the MVIC, the current intensity required to generate a torque of 40 Nm and the maximum intensity tolerated by the participant will be evaluated. Three contractions will be recorded in each condition, and the level of discomfort will be assessed during the evoked contractions. Evoked torque will be evaluated at the maximum tolerated intensity level using the isokinetic dynamometer. Clinical and neuromuscular efficiency will be evaluated (1) at the current intensity necessary to evoke 20% MVIC, (2) at the current intensity necessary to generate 40 Nm, and (3) at the maximum tolerated current intensity. On the fifth and sixth days, muscle fatigue induced by the diferente current types will be evaluated. Fatigue will be evaluated with sufficient current intensity to generate 20% of the MVIC. MVIC will be performed before and after the fatigue protocol, and the fatigue will be determined by the relative variation of the MVIC before and after the fatigue protocol. Fatigue will also be evaluated through the evoked torque variation between the first and the last minute of the fatigue protocol, as well as by the total work generated in each protocol. Neuromuscular efficiency will be evaluated before and immediately after the protocol through (1) the ratio between input NMES current intensity and output evoked torque, (2) total work (area under the evoked force by time curves) generated during the fatigue protocol, and (3) by the changes in muscle architecture from rest to evoked contraction at the maximal current intensity.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.