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NCT03793075
Ketamine Versus Propofol Effect on the Immune-mediatory Response for Abdominal Surgery
NA trial testing Ketamine in Major Abdominal Surgery in 36 participants. Status unknown.
1 June 2019
Quick facts
| Lead sponsor | Mansoura University Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | supportive care |
| Enrollment | 36 |
| Start date | 10 January 2019 |
| Primary completion | 1 June 2019 |
| Estimated completion | 15 August 2019 |
Drugs / interventions tested
Conditions studied
- Major Abdominal Surgery — all drugs for Major Abdominal Surgery →
Sponsor
Mansoura University Hospital
Who can join
Adults 18 to 70, any sex, with Major Abdominal Surgery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Host systemic responses to vigorous stimuli as trauma, surgical tissue injury, anesthesia and post-operative pain, leads to release a variety of pro-inflammatory cytokines including interleukin-1 (IL-1) and interleukin-6 (IL-6) mainly from monocytes and macrophages Thus, the rise of IL-6 is regarded as an early marker of tissue damage and its rise proportional to the degree of tissue damage . It has been demonstrated that systemic responses to stress may be modified by the anesthetic technique used . Total intravenous anesthesia (TIVA) especially propofol based greatly suppresses the stress response induced by surgery when compared to inhalation by lowering cortisol levels. Ketamine has the ability to modulate (modify) inflammation . Even the sub-anesthetic doses of ketamine in animal models were even provided to have an effect on the inflammatory response system in the central nervous system
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03793075
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03793075 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mansoura University Hospital
- Last refreshed: 7 January 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03793075.
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