Last reviewed · How we verify
NCT03787719: D-LITE
Dialysis-Less Frequently In The Elderly
NA trial testing Twice per week dialysis in Dialysis in 49 participants. Completed in 9 November 2023.
11 September 2023
Quick facts
| Lead sponsor | Dr. Christine White |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 49 |
| Start date | 27 June 2018 |
| Primary completion | 11 September 2023 |
| Estimated completion | 9 November 2023 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Twice per week dialysis
Conditions studied
- Dialysis — all drugs for Dialysis →
- End Stage Renal Disease — all drugs for End Stage Renal Disease →
- Hemodialysis — all drugs for Hemodialysis →
Sponsor
Dr. Christine White
Who can join
70 and older, any sex, with Dialysis or End Stage Renal Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Thrice-weekly dialysis is the accepted standard of care for hemodialysis (HD) patients. Observational studies suggest that elderly HD patients do as well and have better quality of life with less dialysis (ie twice-weekly). We propose a single-center pilot study of 40 patients to determine the feasibility of a large randomized controlled trial (RCT) designed to determine the impact of HD frequency on well-being in new HD patients above the age of 70. The primary outcomes will be metrics of feasibility and safety. We hypothesize that an adequately powered RCT that will determine whether elderly patients who dialyze twice weekly have improved well-being compared to thrice-weekly is feasible
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Narrative Review of Incremental Hemodialysis.
Murea M, Moossavi S, Garneata L, Kalantar-Zadeh K. · · 2020 · cited 38× · PMID 32043027 · DOI 10.1016/j.ekir.2019.11.014 -
Pilot Randomized Trial of Dialysis Less Frequently in the Elderly: The DLITE Study.
White CA, Welihinda H, Day AG, Heyland DK, et al · · 2025 · cited 1× · PMID 41278339 · DOI 10.1016/j.ekir.2025.08.043 -
Incremental versus standard dialysis for people with kidney failure
Sabanayagam D, Hegerty K, Au E, Beruni N, et al · · 2023
Verify or expand the search:
- PubMed search for NCT03787719
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Dialysis
Currently open trials in the same condition.
- NCT07262320 — Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America · recruiting
- NCT07013175 — Wise Choices in the Intensive Care Unit · NA · recruiting
- NCT07119593 — Exercise Intensity · NA · recruiting
- NCT06933472 — A Study of a Novel Iron-based Phosphate Binder AP301 in Patients With Hyperphosphatemia in the U.S. and China · Phase 3 · recruiting
- NCT06905080 — Dialysis Catheter Caps Case Feasibility Study · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03787719 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dr. Christine White
- Last refreshed: 1 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03787719.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing