Last reviewed · How we verify
NCT03787641: HART
Systematic Evaluation of Protamine Doze in Cardiac Surgery
NA trial testing Protamine Sulfate in Cardiac Surgery With Cardiopulmonary Bypass in 100 participants. Status unknown.
31 December 2019
Quick facts
| Lead sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 20 September 2018 |
| Primary completion | 31 December 2019 |
| Estimated completion | 28 February 2020 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Protamine Sulfate — full drug profile →
Conditions studied
- Cardiac Surgery With Cardiopulmonary Bypass — all drugs for Cardiac Surgery With Cardiopulmonary Bypass →
Sponsor
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Who can join
18 and older, any sex, with Cardiac Surgery With Cardiopulmonary Bypass. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The precise amount of protamine required to neutralize unfractionated heparin (UFH) remains unknown. This study will systematically identify the doze needed to neutralize UFH following cardiopulmonary bypass (CPB).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Minimum protamine dose required to neutralize heparin in cardiac surgery: a single-centre, prospective, observational cohort study.
Taneja R, Szoke DJ, Hynes Z, Jones PM. · · 2023 · cited 9× · PMID 36471142 · DOI 10.1007/s12630-022-02364-4
Verify or expand the search:
- PubMed search for NCT03787641
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Protamine Sulfate
Trials testing the same drug.
- NCT03140631 — Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation · Phase 4 · completed
Other London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials
Trials by the same sponsor.
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- NCT07585292 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy · NA · not yet recruiting
- NCT07510906 — Evaluation of a Prostate-Targeted PET Imaging System (P-PET) for Detecting Prostate Cancer · NA · not yet recruiting
- NCT03166072 — Health Education vs Meditation in Irreversible Age-Related Vision Loss Patients and Their Caregivers · NA · not yet recruiting
- NCT06035809 — Sensory Motor Arousal Regulation Treatment (SMART) Study · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03787641 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Last refreshed: 31 December 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03787641.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing