Adults 18 to 45, female only, with Obesity, Morbid or Spinal Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Number of Participants With Successful Blocks for Induction (Success Induction)Primary· 10 minutes after intrathecal drug administration
Bilateral T6 sensory level to pinprick
Group
Value
95% CI
Bupivacaine - 9.75 mg
1
Bupivacaine - 10.5 mg
3
Bupivacaine - 11.25 mg
27
Bupivacaine - 12 mg
11
Number of Participants With Successful Blocks for Operation (Success Operation)Primary· during surgery up to 90 minutes after intrathecal injection
Successful initial sensory level without requiring additional epidural anesthetic
Group
Value
95% CI
Bupivacaine - 9.75 mg
0
Bupivacaine - 10.5 mg
2
Bupivacaine - 11.25 mg
21
Bupivacaine - 12 mg
11
ED90 (90% Effective Dose) of Intrathecal Bupivacaine for Cesarean DeliveryPrimary· 90 minutes
Group
Value
95% CI
Bupivacaine - Optimized Dose
11.56
11.16 – 11.99
Sponsor's own description
The aim of this study is to determine the ED90 of hyperbaric intrathecal bupivacaine for the super obese population undergoing cesarean section under a combined spinal epidural technique.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
NCT05785377 — Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia
· NA
· not yet recruiting
NCT07467356 — Anterior Iliopsoas Space Block Versus PENG Block on Ease of Positioning for Spinal Anathesia in Patients Undergoing Hip
· Phase 3
· recruiting
NCT07465185 — Intrathecal Bupivacaine With or Without Dexmetomidine for Cesserian Delivery
· Phase 2
· recruiting
NCT07430085 — Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA
· Phase 4
· not yet recruiting
NCT07146685 — Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study
· Phase 4
· not yet recruiting
Other recruiting trials for Obesity, Morbid
Currently open trials in the same condition.
NCT07119437 — Low Impact Laparoscopy In Bariatric Surgery
· NA
· recruiting
NCT05927519 — Comparison of Airtraq in Class 2-3 Obese and Nonobese Men During Intubation: a Prospective Randomized Clinical Study
· NA
· recruiting
NCT06530212 — Sleeve Gastrectomy With Jejuno-ileal Bypass Versus Single Anastomosis Sleeve Jejunal Bypass
· NA
· recruiting
NCT06477120 — Time-restricted Eating Among Pregnant Females With Severe Obesity
· NA
· recruiting
NCT06119516 — Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
· NA
· recruiting
Other Duke University trials
Trials by the same sponsor.
NCT07216456 — Vaginal Dilator Therapy After Pelvic Radiation
· NA
· not yet recruiting
NCT07519317 — Dosing and Deployment Trial: A Home-based Optokinetic Treatment
· NA
· not yet recruiting
NCT07275359 — Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations
· Phase 1
· not yet recruiting
NCT07216963 — The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study
· NA
· not yet recruiting
NCT07459218 — IDEAS for Hope to Reduce Suicide Risk and Improve HIV Care Engagement in Tanzania
· NA
· not yet recruiting
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Duke University
Last refreshed: 17 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03781388.