NCT03781206 (NESTOR) is a NA clinical trial of PICO™ 7 in Stoma Site Infection, sponsored by Istituto Clinico Humanitas.

Who is sponsoring NCT03781206?

NCT03781206 is sponsored by Istituto Clinico Humanitas.

What drugs are being tested in NCT03781206?

Interventions in NCT03781206: PICO™ 7.

What condition does NCT03781206 study?

NCT03781206 studies Stoma Site Infection.

Is NCT03781206 still recruiting?

NCT03781206 is currently status unknown. Last updated 5 February 2021.

Last reviewed 2021-02-05 · How we verify

NCT03781206: NESTOR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Negative Pressure Wound Therapy for Wound Healing After Stoma Reversal

Status unknown NA Last updated 5 February 2021

What this trial tests

NA trial testing PICO™ 7 in Stoma Site Infection in 100 participants. Status unknown.

Timeline

18 July 2019

Primary endpoint
1 March 2021

1 June 2021

Quick facts

Lead sponsor	Istituto Clinico Humanitas
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	100
Start date	18 July 2019
Primary completion	1 March 2021
Estimated completion	1 June 2021
Sites	1 location across Italy

Drugs / interventions tested

PICO™ 7

Conditions studied

Stoma Site Infection — all drugs for Stoma Site Infection →

Sponsor

Istituto Clinico Humanitas

Who can join

18 and older, any sex, with Stoma Site Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Stoma reversal is associated with high incidence of post-surgical complications, including Surgical Site Infections (SSI). Negative Pressure Wound Therapy (NPWT) has been successfully applied to surgical wound management, reducing the SSIs incidence. This is a randomized open-label trial to assess the efficacy of NPWT in decreasing the rate of SSI after stoma reversal.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Shi C, Goh EL, Murphy EM, et al · · 2022 · cited 71× · PMID 35471497 · DOI 10.1002/14651858.cd009261.pub7
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Goh EL, Dumville JC, Shi C, et al · · 2020 · cited 48× · PMID 32542647 · DOI 10.1002/14651858.cd009261.pub6
Negative pressure wound therapy for surgical wounds healing by primary closure.
Norman G, Goh EL, Dumville JC, Shi C, et al · · 2020 · cited 38× · PMID 32356396 · DOI 10.1002/14651858.cd009261.pub5
Characteristics of Interventional Trials for Patients Living With Intestinal Stoma Registered in ClinicalTrials.gov With a Focus on Inflammatory Bowel Disease.
Vuyyuru SK, Ma C, Sharma T, Nguyen TM, et al · · 2024 · cited 3× · PMID 38135729 · DOI 10.1093/ibd/izad293

Verify or expand the search:

Other Istituto Clinico Humanitas trials

Trials by the same sponsor.

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NCT07346274 — Intra-operative Hypotension and Post-operative Lactate Level After Pancreatic-duodenectomy. · enrolling by invitation
NCT07491419 — The Impact of Fast Antimicrobial Sensitivity Testing Tools on Stewardship Antibiotic and Clinical Outcome (ACT-FAST) · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03781206 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Istituto Clinico Humanitas
Last refreshed: 5 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03781206.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing