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NCT03781011
Oral Carnitine Challenge Test Guides Personalized Nutrition for CV Patients
NA trial testing Vegetarian diet intervention in Dietary Modification in 50 participants. Completed in 19 October 2020.
19 October 2019
Quick facts
| Lead sponsor | National Taiwan University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 50 |
| Start date | 19 October 2018 |
| Primary completion | 19 October 2019 |
| Estimated completion | 19 October 2020 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Vegetarian diet intervention
Conditions studied
- Dietary Modification — all drugs for Dietary Modification →
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
Sponsor
National Taiwan University Hospital
Who can join
20 and older, any sex, with Dietary Modification or Cardiovascular Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators plan to use the recently developed oral carnitine challenge test (OCCT) as a tool to exam individual's trimethylamine N-oxide (TMAO) production capacity from their gut microbiota. By using data collected by OCCT, the investigators defined subjects as high-TMAO producer or low-TMAO producer and apply low carnitine/choline diet as dietary intervention for the high-TMAO producers. After dietary intervention for two months, the investigators conducted OCCT for the participants and compare the TMAO production capacity before and after the dietary intervention.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery.
Wu WK, Panyod S, Liu PY, Chen CC, et al · · 2020 · cited 38× · PMID 33213511 · DOI 10.1186/s40168-020-00912-y -
Gut microbes with the <i>gbu</i> genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition.
Wu WK, Lo YL, Chiu JY, Hsu CL, et al · · 2025 · cited 5× · PMID 39722590 · DOI 10.1080/19490976.2024.2446374
Verify or expand the search:
- PubMed search for NCT03781011
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other National Taiwan University Hospital trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03781011 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Taiwan University Hospital
- Last refreshed: 18 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03781011.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing