Last reviewed · How we verify
NCT03779399
Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor
trial testing Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA. in Ovarian Cancer in 60 participants. Completed in 31 December 2016.
31 May 2014
Quick facts
| Lead sponsor | Medical University of Lublin |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 60 |
| Start date | 1 December 2011 |
| Primary completion | 31 May 2014 |
| Estimated completion | 31 December 2016 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
Conditions studied
- Ovarian Cancer — all drugs for Ovarian Cancer →
- Borderline Ovarian Tumors — all drugs for Borderline Ovarian Tumors →
- Benign Ovarian Tumor — all drugs for Benign Ovarian Tumor →
- Unexplained Infertility — all drugs for Unexplained Infertility →
Sponsor
Medical University of Lublin
Who can join
Adults 18 to 75, female only, with Ovarian Cancer or Borderline Ovarian Tumors. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study was to estimate the percentage and of Treg, Th17 and NKT in peripheral blood and the tissue of the epithelial ovarian tumor and relationship with blood serum level of HE4, CA125, as well as algorithm ROMA. Material and methods Mononuclear cells (PBMCs) were isolated by density gradient centrifugation obtained from peripheral blood and ovarian tissue of patient suffering ovarian pathology. Patient from control group underwent surgery for unexplanied infertility. The percentage of Treg and Th17 , NKT in peripheral blood and the tissue was assessed using the flow cytometry method according to the manufacturer's instructions. The ROMA index was calculated according to the levels of HE4 and CA-125 in serum.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application.
Pan Y, Zhou H, Sun Z, Zhu Y, et al · · 2025 · cited 19× · PMID 40216744 · DOI 10.1038/s41419-025-07544-w -
Promising Cellular Immunotherapy for Colorectal Cancer Using Classical Dendritic Cells and Natural Killer T Cells.
Singer M, Valerin J, Zhang Z, Zhang Z, et al · · 2025 · cited 6× · PMID 39936958 · DOI 10.3390/cells14030166
Verify or expand the search:
- PubMed search for NCT03779399
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Ovarian Cancer
Currently open trials in the same condition.
- NCT06412120 — Study Evaluating Safety, Tolerability, and Metabolism of Niraparib · Phase 4 · recruiting
- NCT06930755 — Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer · Phase 1 · recruiting
- NCT07318558 — A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021) · Phase 3 · recruiting
- NCT07491081 — EARLY Study: Evaluating the Specificity and Feasibility of the EARLY Biomarker Panel for Ovarian Cancer Detection · NA · recruiting
- NCT07410676 — EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors · Phase 1, PHASE2 · recruiting
Other Medical University of Lublin trials
Trials by the same sponsor.
- NCT07085286 — Perfusion Related Evaluation of Systemic and Renal Vulnerability to Events in CABG · not yet recruiting
- NCT06897436 — Characterization of Immune Cells and Their Secreted Cytokines in Endometriosis Patients · not yet recruiting
- NCT06516835 — Diluted and Undiluted Enteral Nutrition · NA · not yet recruiting
- NCT07182318 — Validation of the FIGO Nutrition Checklist in Pregnant Women · completed
- NCT06282666 — Lumbar ESPB in Hip Replacement Surgery · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03779399 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University of Lublin
- Last refreshed: 19 December 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03779399.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing