Angiotensin-(1-7) and Energy Expenditure in Human Obesity

NCT03777215 EARLY_PHASE1 ACTIVE_NOT_RECRUITING

The objective of this study is to better define the role of the hormone angiotensin-(1-7) in energy balance. We will test the overall hypothesis that angiotensin-(1-7) increases resting energy expenditure and promotes markers of heat production (thermogenesis) in white adipose tissue in human obesity.

Details

Lead sponsor	Amy Arnold
Phase	EARLY_PHASE1
Status	ACTIVE_NOT_RECRUITING
Enrolment	30
Start date	2019-09-26
Completion	2026-12

Conditions

• Obesity

Interventions

• Angiotensin-(1-7)
• Saline

Primary outcomes

• Resting energy expenditure — 120 minutes
  Change in resting energy expenditure measured by indirect calorimetry at baseline and at end of angiotensin-(1-7) versus saline infusion.
• Uncoupling protein 1 — 120 minutes
  White adipose tissue biopsies will be taken at end of angiotensin-(1-7) versus saline infusion to assess gene expression of the heat producing (thermogenic) marker uncoupling protein 1.

Countries

United States