NCT03776383: OPTIMISE

Providing Antibiotic Prescribing Feedback to Primary Care Physicians: The Ontario Program To Improve AntiMicrobial USE

Completed NA Last updated 3 March 2021

What this trial tests

NA trial testing Antibiotic use feedback letter in Antibiotic Prescribing Audit and Feedback in 3,500 participants. Completed in 30 November 2020.

Timeline

14 December 2018

Primary endpoint
30 November 2019

30 November 2020

Quick facts

Lead sponsor	Ontario Agency for Health Protection and Promotion
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	health services research
Enrollment	3,500
Start date	14 December 2018
Primary completion	30 November 2019
Estimated completion	30 November 2020
Sites	1 location across Canada

Drugs / interventions tested

• Antibiotic use feedback letter

Conditions studied

• Antibiotic Prescribing Audit and Feedback — all drugs for Antibiotic Prescribing Audit and Feedback →

Sponsor

Ontario Agency for Health Protection and Promotion

Who can join

Eligibility, any sex, with Antibiotic Prescribing Audit and Feedback. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Antibiotic overuse occurs in multiple jurisdictions and is associated with rising rates of antimicrobial resistance. Mailing letters to the highest antibiotic prescribing physicians is a potentially effective method to optimize antibiotic use. The objectives of this study are to improve enrollment to Health Quality Ontario's Primary Care Practice report and reduce unnecessary antibiotic use. The investigators are conducting a randomized controlled trial recruiting the 3500 highest antibiotic prescribing primary care physicians in Ontario. The investigators have incorporated behavioural science theory into designing letters to modify prescribing behaviour. Letter 1 is testing change ideas related to antibiotic initiation and letter 2 is testing change ideas related to antibiotic duration. There will be 1500 physicians receiving letter 1, 1500 receiving letter 2, and 500 will serve as controls. Twelve months later all 3500 physicians will receive a letter.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effect of Antibiotic-Prescribing Feedback to High-Volume Primary Care Physicians on Number of Antibiotic Prescriptions: A Randomized Clinical Trial.
   Schwartz KL, Ivers N, Langford BJ, Taljaard M, et al · · 2021 · cited 44× · PMID 34228086 · DOI 10.1001/jamainternmed.2021.2790
2. Validating a popular outpatient antibiotic database to reliably identify high prescribing physicians for patients 65 years of age and older.
   Schwartz KL, Chen C, Langford BJ, Brown KA, et al · · 2019 · cited 20× · PMID 31557249 · DOI 10.1371/journal.pone.0223097
3. 2020 Annual Conference Conférence Annuelle.
   · 2021 · PMID 36339318 · DOI 10.3138/jammi.6.s1.abst
4. Oral Presentations
   Xia Y, Tunis M, Frenette C, Katz K, et al ·