NCT03774017 (HOTAVM) is a NA clinical trial of one-staged hybrid operation in Cerebrovascular Disease, sponsored by Ministry of Science and Technology of the People´s Republic of China.

Who is sponsoring NCT03774017?

NCT03774017 is sponsored by Ministry of Science and Technology of the People´s Republic of China.

What drugs are being tested in NCT03774017?

Interventions in NCT03774017: one-staged hybrid operation, Traditional microsurgical operation.

What condition does NCT03774017 study?

NCT03774017 studies Cerebrovascular Disease, Arteriovenous Malformations, Complex; Primary.

Is NCT03774017 still recruiting?

NCT03774017 is currently status unknown. Last updated 12 December 2018.

Last reviewed 2018-12-12 · How we verify

NCT03774017: HOTAVM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Research on Hybrid Operation Technique in the Treatment of Complex Brain Arteriovenous Malformations

Status unknown NA Last updated 12 December 2018

What this trial tests

NA trial testing one-staged hybrid operation in Cerebrovascular Disease in 1,200 participants. Status unknown.

Timeline

1 January 2016

Primary endpoint
1 October 2020

31 December 2020

Quick facts

Lead sponsor	Ministry of Science and Technology of the People´s Republic of China
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	1,200
Start date	1 January 2016
Primary completion	1 October 2020
Estimated completion	31 December 2020
Sites	7 locations across China

Drugs / interventions tested

one-staged hybrid operation
Traditional microsurgical operation

Conditions studied

Cerebrovascular Disease — all drugs for Cerebrovascular Disease →
Arteriovenous Malformations — all drugs for Arteriovenous Malformations →
Complex; Primary — all drugs for Complex; Primary →

Sponsor

Ministry of Science and Technology of the People´s Republic of China

Who can join

Under 70, any sex, with Cerebrovascular Disease or Arteriovenous Malformations. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Complex brain arteriovenous malformations (bAVMs) in ≥3 Spetzler-Martin grades have long been challenges among cerebrovascular diseases. None of the traditional methods, such as microsurgical operation, endovascular intervention, or stereotactic radiotherapy, can completely eliminate complex bAVMs without a risk of neural function deterioration. The multistaged hybrid operation solved part of the challenge but remained risky in the installment procedures and intervals. The one-staged hybrid operation was applied in the surgical treatment of cerebrovascular diseases and proved to be a potentially safe and effective method for curing complex bAVMs. However, lacking the support of high-level evidence, its advantages remain unclear. This study was proposed to validate the benefits and risks of one-staged hybrid operation in the treatment of complex bAVMs, as well as its indications, key technologies, and workflows.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

One-staged in situ embolization combined with surgical resection for eloquence protection of AVM: technical note.
Wang M, Qiu H, Cao Y, Wang S, et al · · 2019 · cited 13× · PMID 31359304 · DOI 10.1007/s10143-019-01137-w
Multimodal treatments of brain arteriovenous malformations: a comparison of microsurgical timings after endovascular embolization.
Zeng C, Wang M, Song X, Zhang C, et al · · 2022 · cited 8× · PMID 35957722 · DOI 10.21037/atm-22-811
State of the Art in the Role of Endovascular Embolization in the Management of Brain Arteriovenous Malformations-A Systematic Review.
Pinkiewicz M, Pinkiewicz M, Walecki J, Zawadzki M. · · 2022 · cited 7× · PMID 36498782 · DOI 10.3390/jcm11237208
Multimodality Treatment of Brain Arteriovenous Malformations with One-Staged Hybrid Operation: Clinical Characteristics and Long-Term Prognosis.
Jiang Y, Zeng C, Zhang Y, Xu X, et al · · 2022 · cited 6× · PMID 35265225 · DOI 10.1155/2022/2559004
Surgical management of complex brain arteriovenous malformations with hybrid operating technique: study protocol of a prospective registry and a pragmatic clinical trial.
Wang M, Jiao Y, Cao Y, Wang S, et al · · 2019 · cited 6× · PMID 31039755 · DOI 10.1186/s12883-019-1289-3
Comparison of Endovascular Embolization Plus Simultaneous Microsurgical Resection vs. Primary Microsurgical Resection for High-Grade Brain Arteriovenous Malformations.
Wang M, Lin F, Qiu H, Cao Y, et al · · 2021 · cited 5× · PMID 35002920 · DOI 10.3389/fneur.2021.756307
Emergency neurosurgical hybrid operating platform for acute intracranial hemorrhage (E-HOPE).
Wang M, Ge P, Jiao Y, Deng X, et al · · 2024 · PMID 39676158 · DOI 10.1186/s41016-024-00385-0

Verify or expand the search:

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Other Ministry of Science and Technology of the People´s Republic of China trials

Trials by the same sponsor.

NCT06730243 — Retzius-sparing Robot-assisted Radical Prostatectomy With "Sandwich" Technique of Total Urethral Reconstruction Versus S · NA · recruiting
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NCT03820882 — Stent Retriever for Thrombectomy Revascularisation of Large Vessel Occlusions in Acute Ischemic Stroke(Catfish) · NA · completed
NCT03753061 — Intracranial Thrombosis Aspiration Catheter for Recanalization in Acute Ischemic Stroke Therapy (RECOVER) · NA · unknown
NCT04051567 — Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies · Phase 4 · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03774017 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ministry of Science and Technology of the People´s Republic of China
Last refreshed: 12 December 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03774017.

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