Last reviewed · How we verify
NCT03773003: IMPROFA
Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME)
NA trial testing Probiotics in Cancer Related Fatigue in 150 participants. Currently enrolling.
1 July 2025
Quick facts
| Lead sponsor | Universität des Saarlandes |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 150 |
| Start date | 20 July 2021 |
| Primary completion | 1 July 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Probiotics — full drug profile →
- Placebo
Conditions studied
- Cancer Related Fatigue — all drugs for Cancer Related Fatigue →
- Fatigue Syndrome, Chronic — all drugs for Fatigue Syndrome, Chronic →
Sponsor
Universität des Saarlandes — full company profile →
Who can join
Adults 18 to 80, any sex, with Cancer Related Fatigue or Fatigue Syndrome, Chronic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue Syndrome (CFS/ME) by Lipidomics, Metabolomics, Intestinal and Peritoneal Microbiome Analysis and Exome Analysis and Investigation of a Possible Benefit of Probiotics.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).
König RS, Albrich WC, Kahlert CR, Bahr LS, et al · · 2021 · cited 82× · PMID 35046929 · DOI 10.3389/fimmu.2021.628741 -
Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas.
You L, Zhou J, Xin Z, Hauck JS, et al · · 2022 · cited 23× · PMID 35692444 · DOI 10.1093/pcmedi/pbac005 -
Targeting gut microbiota and metabolites in cancer radiotherapy.
Ma S, Li X, Shang S, Zhai Z, et al · · 2025 · cited 3× · PMID 41028942 · DOI 10.1002/ctm2.70481
Verify or expand the search:
- PubMed search for NCT03773003
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Probiotics
Trials testing the same drug.
- NCT07470645 — Effects of Probiotic Supplementation on Stress and Anxiety in Students · NA · not yet recruiting
- NCT06943235 — Study of Probiotics Combined With Concurrent Hyperfractionated ChemoRadiotherapy and Adebrelimab Immunomaintenance in th · Phase 2 · recruiting
- NCT06827964 — Practice of Nutrition Package in Myanmar · NA · not yet recruiting
- NCT06873165 — Development of Microbial Therapeutics for Metabolic-associated Fatty Liver Disease: From Mechanistic Investigations to C · NA · recruiting
- NCT06583720 — Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the Treatment of Halitosis · Phase 1 · recruiting
Other Universität des Saarlandes trials
Trials by the same sponsor.
- NCT07530809 — Time-restricted Feeding in MASLD · NA · recruiting
- NCT06865950 — Sex diffErences in prehoSpitAl Stroke MEdicine · recruiting
- NCT06907563 — Long-term Follow-up to Determine Outcome in Liver Disease (LOVE Study) · not yet recruiting
- NCT06453577 — Pharmacokinetics of Bisoprolol and SGLT2i in Acutely Decompensated Heart Failure · active not recruiting
- NCT06459115 — Adherence to Medication in Patients With Acute Decompensated Heart Failure · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03773003 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universität des Saarlandes
- Last refreshed: 29 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03773003.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing