NCT03770286 is a NA clinical trial of 5% Fluoride Varnish in Dental Caries in Children, sponsored by Children's Hospital Los Angeles.

Who is sponsoring NCT03770286?

NCT03770286 is sponsored by Children's Hospital Los Angeles.

What drugs are being tested in NCT03770286?

Interventions in NCT03770286: 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss.

What condition does NCT03770286 study?

NCT03770286 studies Dental Caries in Children, Dental Caries Class II, Dental Caries.

Is NCT03770286 still recruiting?

NCT03770286 is currently completed. Last updated 15 October 2024.

Are results published for NCT03770286?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2024-10-15 · How we verify

NCT03770286

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride

Completed NA Results posted Last updated 15 October 2024

What this trial tests

NA trial testing 5% Fluoride Varnish in Dental Caries in Children in 51 participants. Completed in 31 May 2023.

Timeline

22 January 2019

Primary endpoint
31 May 2023

31 May 2023

Quick facts

Lead sponsor	Children's Hospital Los Angeles
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	51
Start date	22 January 2019
Primary completion	31 May 2023
Estimated completion	31 May 2023
Sites	1 location across United States

Drugs / interventions tested

5% Fluoride Varnish
38% Silver diamine fluoride
Super Floss

Conditions studied

Dental Caries in Children — all drugs for Dental Caries in Children →
Dental Caries Class II — all drugs for Dental Caries Class II →
Dental Caries — all drugs for Dental Caries →

Sponsor

Children's Hospital Los Angeles

Who can join

Adults 3 to 12, any sex, with Dental Caries in Children or Dental Caries Class II. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Interproximal Caries Zone of Radiolucency Primary · Baseline to 6 months

Bitewing radiographs will be taken of target lesions at Day 1 (baseline). Target interproximal carious lesion(s) will be rated based on the zone of radiolucency on the radiographs using the International Caries Classification and Management System (ICCMS). Category 1 = Progression Category 2 = Stabilization Category 3 = Remineralization

Category 1 = Progression

Group	Value	95% CI
Fluoride Varnish Alone	9
SDF With Super Floss	7
SDF Without Super Floss	10

Category 2 = Stabilization

Group	Value	95% CI
Fluoride Varnish Alone	12
SDF With Super Floss	31
SDF Without Super Floss	22

Category 3 = Remineralization

Group	Value	95% CI
Fluoride Varnish Alone	10
SDF With Super Floss	6
SDF Without Super Floss	11

Interproximal Caries Zone of Radiolucency Primary · 6 months to 12 months

Bitewing radiographs will be taken of target lesions at 6 months and compared. Target interproximal carious lesion(s) will be rated based on the zone of radiolucency on the radiographs using the International Caries Classification and Management System (ICCMS). Category 1 = Progression Category 2 = Stabilization Category 3 = Remineralization

Category 1 = Progression

Group	Value	95% CI
Fluoride Varnish Alone	6
SDF With Super Floss	3
SDF Without Super Floss	9

Category 2 = Stabilization

Group	Value	95% CI
Fluoride Varnish Alone	3
SDF With Super Floss	13
SDF Without Super Floss	10

Category 3 = Remineralization

Group	Value	95% CI
Fluoride Varnish Alone	3
SDF With Super Floss	3
SDF Without Super Floss	2

Interproximal Caries Zone of Radiolucency Primary · Baseline to 12 months

Bitewing radiographs will be taken of target lesions at 12 months and compared. Target interproximal carious lesion(s) will be rated based on the zone of radiolucency on the radiographs using the International Caries Classification and Management System (ICCMS). Category 1 = Progression Category 2 = Stabilization Category 3 = Remineralization

Category 1 = Progression

Group	Value	95% CI
Fluoride Varnish Alone	8
SDF With Super Floss	8
SDF Without Super Floss	10

Category 2 = Stabilization

Group	Value	95% CI
Fluoride Varnish Alone	10
SDF With Super Floss	20
SDF Without Super Floss	13

Category 3 = Remineralization

Group	Value	95% CI
Fluoride Varnish Alone	6
SDF With Super Floss	5
SDF Without Super Floss	7

Sponsor's own description

This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective in arresting or remineralizing initial interproximal lesion in comparison to SDF applied without Super Floss or fluoride varnish applied alone.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults.
Worthington HV, Lewis SR, Glenny AM, Huang SS, et al · · 2024 · cited 8× · PMID 39508296 · DOI 10.1002/14651858.cd012718.pub2

Verify or expand the search:

Other recruiting trials for Dental Caries in Children

Currently open trials in the same condition.

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Other Children's Hospital Los Angeles trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03770286 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Children's Hospital Los Angeles
Last refreshed: 15 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03770286.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing

NCT03770286

Quick facts

Drugs / interventions tested

Conditions studied

Sponsor

Who can join

Results — posted to ClinicalTrials.gov

Sponsor's own description

Publications & conference data

Related trials

Other recruiting trials for Dental Caries in Children

Other Children's Hospital Los Angeles trials

Verify against primary sources