Last reviewed · How we verify
NCT03766542
Continuous Positive Pressure Versus Bi-level in Overlap Syndrome
NA trial testing Bi-level positive airway pressure with ventilatory support in Overlap Syndrome in 70 participants. Status unknown.
1 July 2020
Quick facts
| Lead sponsor | Hospital Sao Joao |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 70 |
| Start date | 1 January 2019 |
| Primary completion | 1 July 2020 |
| Estimated completion | 1 September 2020 |
Drugs / interventions tested
- Bi-level positive airway pressure with ventilatory support
- continuous positive airway pressure without ventilatory support
Conditions studied
- Overlap Syndrome — all drugs for Overlap Syndrome →
- Nocturnal Hypoventilation — all drugs for Nocturnal Hypoventilation →
Sponsor
Hospital Sao Joao
Who can join
40 and older, any sex, with Overlap Syndrome or Nocturnal Hypoventilation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Continuous positive airway pressure (CPAP) became the established treatment for overlap syndrome (OS). It has been showed that the survival benefits of CPAP favored hypercapnic patients. When considering hypercapnic stable COPD patients, survival benefits occurred when the use of bi- level ventilation therapy was targeted to significantly reduce hypercapnia. This highlights the relevance of hypercapnia and hypoventilation correction. Thus, the purpose of this study is to compare the use of CPAP to Bi-level ventilation in hypercapnic OS patients, since the later may correct not only the airway patency but also increase the magnitude of each breath.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A review of therapies for the overlap syndrome of obstructive sleep apnea and chronic obstructive pulmonary disease.
Suri TM, Suri JC. · · 2021 · cited 17× · PMID 34485837 · DOI 10.1096/fba.2021-00024
Verify or expand the search:
- PubMed search for NCT03766542
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Overlap Syndrome
Currently open trials in the same condition.
- NCT05237505 — The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome) · Phase 2 · recruiting
- NCT05958563 — Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA · NA · recruiting
- NCT04179981 — Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Dis · NA · recruiting
Other Hospital Sao Joao trials
Trials by the same sponsor.
- NCT05335642 — Secondary Intervention and Surveillance After EVAR · completed
- NCT04068714 — Open Versus Endovascular Repair of Abdominal Aortic Aneurysms · completed
- NCT04085003 — Intact Abdominal Aortic Aneurysm Repair in Portugal · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03766542 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Sao Joao
- Last refreshed: 6 December 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03766542.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing