Last reviewed · How we verify
Tranexamic Acid Versus Fractional CO2 Laser in Post-inflammatory Hyperpigmentation in Acne Patients
comparing between the effect of intradermal injection of TXA and low power low density fractional CO2 lasers on post acne hyperpigmentation
Details
| Lead sponsor | Cairo University |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 25 |
| Start date | 2018-12 |
| Completion | 2019-07 |
Conditions
- Post Inflammatory Hyperpigmentation
Interventions
- Tranexamic Acid
- Fractional CO2 laser
Primary outcomes
- Measurement of melanin index to assess change of post-acne hyperpigmentation — 3 months
the melanin index (MI) average is 1.10 +/-0.29 with higher values showing worse outcome. It will be measured using reflectance spectrophotometer in order to assess the degree of hyperpigmentation - Measurement of erythema index to assess change of post-acne hyperpigmentation — 3 months
the erythema index (EI) average is 1.29 +/- 0.38 with higher values showing worse outcome. It will be measured using reflectance spectrophotometer in order to assess the degree of erythema - Measurement of post-acne hyperpigmentation index to assess change of post-acne hyperpigmentation — 3 months
the post-acne hyperpigmentation index (PAHPI) ranges from 6-22 with higher values showing worse outcome. It is a summation of three scores (Postinflammatory hyperpigmentation(PIH) lesion size, median lesion intensity compared with surrounding skin and the number of PIH lesions). - Patient satisfaction score to assess change of post-acne hyperpigmentation — 3 months
It is a score ranging from 1-4 with improvement 0-25%=1, 26-50%= 2, 51-75%=3 and more than 75%=4 so higher values of patient satisfaction score showing better outcome