NCT03764319 is a NA clinical trial of Ultra-protective ventilator settings in ARDS, sponsored by Medical University of Vienna.

Who is sponsoring NCT03764319?

NCT03764319 is sponsored by Medical University of Vienna.

What drugs are being tested in NCT03764319?

Interventions in NCT03764319: Ultra-protective ventilator settings, Standard ventilator settings.

What condition does NCT03764319 study?

NCT03764319 studies ARDS, Acute Lung Injury, Extracorporeal Membrane Oxygenation, Respiratory Distress Syndrome, Respiratory Tract Diseases, Lung Diseases, Lung Injury, Acute.

Is NCT03764319 still recruiting?

NCT03764319 is currently completed. Last updated 17 April 2025.

Last reviewed 2025-04-17 · How we verify

NCT03764319

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO

Completed NA Last updated 17 April 2025

What this trial tests

NA trial testing Ultra-protective ventilator settings in ARDS in 44 participants. Completed in 1 August 2021.

Timeline

6 November 2018

Primary endpoint
1 August 2021

1 August 2021

Quick facts

Lead sponsor	Medical University of Vienna
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	44
Start date	6 November 2018
Primary completion	1 August 2021
Estimated completion	1 August 2021
Sites	1 location across Austria

Drugs / interventions tested

Ultra-protective ventilator settings
Standard ventilator settings

Conditions studied

ARDS — all drugs for ARDS →
Acute Lung Injury — all drugs for Acute Lung Injury →
Extracorporeal Membrane Oxygenation — all drugs for Extracorporeal Membrane Oxygenation →
Respiratory Distress Syndrome — all drugs for Respiratory Distress Syndrome →

Sponsor

Medical University of Vienna

Who can join

Adults 18 to 99, any sex, with ARDS or Acute Lung Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure, presented in 10% of all intensive care patients and carrying a high mortality rate. Extracorporeal membrane oxygenation (ECMO) is a rescue treatment for patients with severe ARDS. Mechanical ventilator settings in patients with severe ARDS during ECMO therapy are not clearly defined at the moment.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Extracorporeal Gas Exchange for Acute Respiratory Distress Syndrome: Open Questions, Controversies and Future Directions.
Giani M, Giani M, Redaelli S, Siragusa A, et al · · 2021 · cited 10× · PMID 33670987 · DOI 10.3390/membranes11030172
Mechanical Ventilation during Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: A Narrative Review.
Chiu LC, Kao KC. · · 2021 · cited 9× · PMID 34768478 · DOI 10.3390/jcm10214953
Low-Frequency Ventilation May Facilitate Weaning in Acute Respiratory Distress Syndrome Treated with Extracorporeal Membrane Oxygenation: A Randomized Controlled Trial.
Hermann M, König S, Laxar D, Krall C, et al · · 2024 · cited 1× · PMID 39274307 · DOI 10.3390/jcm13175094

Verify or expand the search:

Other recruiting trials for ARDS

Currently open trials in the same condition.

NCT07362537 — Enteral Nutrition Delivery in Prone Position Ventilated Patients With Moderate to Severe ARDS · NA · recruiting
NCT07298889 — High PEEP in Noninvasive Ventilation Patients With Pneumonia or ARDS · NA · recruiting
NCT07193719 — Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children · Phase 1, PHASE2 · recruiting
NCT07370610 — Electrical Impedance Tomography-Based Dynamic Ventilation-Perfusion Functional Phenotype Trajectory in Acute Respiratory · active not recruiting
NCT06647784 — Lateral Positioning and Prone Positioning in ARDS Patients · NA · recruiting

Other Medical University of Vienna trials

Trials by the same sponsor.

NCT07473401 — Retinal Oxygen Metabolism in Children With Myopia · not yet recruiting
NCT07511400 — The Role of NaV1.8 in Human Pain Models · EARLY_PHASE1 · not yet recruiting
NCT07516990 — Intramuscular Injection of Mashed Parathyroid Tissue Into a Forearm During Thyroid Surgery to Prevent Permanent Postoper · NA · recruiting
NCT07496437 — Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation? · NA · not yet recruiting
NCT07290712 — Post-Intensive Care Syndrome - Multicentre Prospective Registry Database of the DACH Region · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03764319 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Vienna
Last refreshed: 17 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03764319.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing