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Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics (YOBIOTIC)
The focus of the study is to better understand the mechanisms causing antibiotic-associated diarrhea (AAD) and how probiotics may prevent some of the iatrogenic effects of antibiotic medications. One of the most common indications for probiotics is for prevention of antibiotic-associated diarrhea. Clinically, different probiotic strains have demonstrated the ability to prevent AAD; however, the mechanism of action behind this effect has not been elucidated. Data from several studies suggest that antibiotic-induced disruption of commensal bacteria in the colon results in a significant (up to 50%) reduction in short chain fatty acid (SCFA) production and a concomitant reduction in Na-dependent fluid absorption resulting in AAD. Probiotics have been shown to ameliorate a variety of gastrointestinal disease states and thus, the study investigators hypothesize that administration of a probiotic yogurt will protect against the development of AAD.
Details
| Lead sponsor | Georgetown University |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | COMPLETED |
| Enrolment | 66 |
| Start date | Tue Jul 23 2019 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Jan 08 2020 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Antibiotic-associated Diarrhea
Interventions
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet
- BB-12
- Control
Countries
United States