Adults 21 to 80, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Maximum Cross-correlation CoefficientPrimary· After 20 minutes of training under each perceptual cue condition
Cross-correlation between tangential velocity profiles of the two hands was used to index spatial and temporal coordination between hands. Cross-correlation measures similarities of two distinct time series as a function of the displacement of one relative to the other. Repeated correlations between the two hand velocity profiles were obtained as the velocity profile of one hand was successively lagged. The maximum cross correlation coefficient obtained gave a measure of similarity between the two profiles, indexing spatial coordination. The better the arms moved in space, the higher the score
Condition 1: Indiscriminate-Baseline
Group
Value
95% CI
Neurotypical Control
0.989
± 0.014
Stroke Survivors
0.945
± 0.064
Condition 1: Indiscriminate-End of practice
Group
Value
95% CI
Neurotypical Control
0.995
± .006
Stroke Survivors
0.996
± .005
Condition 2: Altered gain- Baseline
Group
Value
95% CI
Neurotypical Control
0.985
± 0.016
Stroke Survivors
0.951
± 0.05
Condition 2: Altered gain: End of practice
Group
Value
95% CI
Neurotypical Control
0.998
± 0.003
Stroke Survivors
0.997
± 0.003
Condition 3: Coordination: Baseline
Group
Value
95% CI
Neurotypical Control
0.957
± 0.068
Stroke Survivors
0.933
± 0.065
Condition 3: Coordination: End of practice
Group
Value
95% CI
Neurotypical Control
0.998
± 0.002
Stroke Survivors
0.995
± 0.006
Condition 4: Dual: Baseline
Group
Value
95% CI
Neurotypical Control
0.873
± 0.184
Stroke Survivors
0.861
± 0.097
Condition 4: Dual: End of practice
Group
Value
95% CI
Neurotypical Control
0.997
± 0.003
Stroke Survivors
0.990
± 0.018
Between Hands Time-lagPrimary· After 20 minutes of training under each perceptual cue condition
Temporal coordination is about how well both arms move at the same time. Temporal coordination was quantified as the time lag at which the peak cross-correlation coefficient was obtained via cross-correlation analysis. If one arm moves a little later than the other, there's a time delay (or time lag). Shorter the delay, the better the timing between the arms. If the delay is positive, it means the weaker or less-used arm is moving after the stronger one.
Condition 1: Indiscriminate: Baseline
Group
Value
95% CI
Neurotypical Control
19.57
± 24.04
Stroke Survivors
72.75
± 149.08
Condition 1: Indiscriminate: End of Practice
Group
Value
95% CI
Neurotypical Control
0.35
± 0.95
Stroke Survivors
1.55
± 7.59
Condition 2: Altered gain: Baseline
Group
Value
95% CI
Neurotypical Control
15.92
± 18.31
Stroke Survivors
51.51
± 64.83
Condition 2: Altered gain: End of Practice
Group
Value
95% CI
Neurotypical Control
0.42
± 1.25
Stroke Survivors
0.04
± 0.29
Condition 3: Coordination: Baseline
Group
Value
95% CI
Neurotypical Control
28.64
± 27.06
Stroke Survivors
49.15
± 48.81
Condition 3: Coordination: End of Practice
Group
Value
95% CI
Neurotypical Control
0.21
± 1.13
Stroke Survivors
8.44
± 19.49
Condition 4: Dual: Baseline
Group
Value
95% CI
Neurotypical Control
107.85
± 121.29
Stroke Survivors
152.44
± 188.30
Condition 4: Dual: End of Practice
Group
Value
95% CI
Neurotypical Control
0.071
± 0.377
Stroke Survivors
26.48
± 76.15
Sponsor's own description
Significant difficulty in incorporating the weaker arm in daily activities after stroke is, in part, driven by difficulty in engaging both arms interactively in a coordinated manner.
The current study aims to determine the nature of bimanual coordination deficits after stroke and takes initial steps to test a novel theory-driven approach to improve interactive bimanual coordination in patients with stroke. This project will advance stroke rehabilitation by identifying novel, scientifically-based strategies to improve the engagement of the weaker arm in coordinated and interactive bimanual actions of daily life, thus improving quality of life in individuals after stroke.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Albert Einstein Healthcare Network
Last refreshed: 14 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03755076.