NCT03752125 is a NA clinical trial of Flavonoid, caffeine in Diet Modification, sponsored by Appalachian State University.

Who is sponsoring NCT03752125?

NCT03752125 is sponsored by Appalachian State University.

What drugs are being tested in NCT03752125?

Interventions in NCT03752125: Flavonoid, caffeine, Placebo.

What condition does NCT03752125 study?

NCT03752125 studies Diet Modification.

Is NCT03752125 still recruiting?

NCT03752125 is currently completed. Last updated 5 July 2019.

Last reviewed 2019-07-05 · How we verify

NCT03752125

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Influence of Flavonoids and Caffeine Supplementation on Resting Metabolism

Completed NA Last updated 5 July 2019

What this trial tests

NA trial testing Flavonoid, caffeine in Diet Modification in 25 participants. Completed in 19 April 2019.

Timeline

22 April 2018

Primary endpoint
15 December 2018

19 April 2019

Quick facts

Lead sponsor	Appalachian State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	25
Start date	22 April 2018
Primary completion	15 December 2018
Estimated completion	19 April 2019
Sites	1 location across United States

Drugs / interventions tested

Flavonoid, caffeine
Placebo

Conditions studied

Diet Modification — all drugs for Diet Modification →

Sponsor

Appalachian State University

Who can join

Adults 20 to 47, female only, with Diet Modification. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to compare the effect of ingesting caffeine and mixed flavonoids (4 capsules, split between breakfast and lunch) on energy expenditure and fat oxidation in a metabolic chamber with 20 women (non-obese, healthy, ages 20-47 years, pre-menopausal). We hypothesize that based on the existing literature, ingestion of a double dose of the caffeine-mixed flavonoid supplement compared to placebo will increase fat oxidation and increase 24 h energy expenditure by about 75 kilocalories.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Acute Ingestion of a Mixed Flavonoid and Caffeine Supplement Increases Energy Expenditure and Fat Oxidation in Adult Women: A Randomized, Crossover Clinical Trial.
Nieman DC, Simonson A, Sakaguchi CA, Sha W, et al · · 2019 · cited 6× · PMID 31694152 · DOI 10.3390/nu11112665

Verify or expand the search:

Other recruiting trials for Diet Modification

Currently open trials in the same condition.

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Other Appalachian State University trials

Trials by the same sponsor.

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NCT06495190 — Cognition, Flavonoids, Exercise, Gut Microbiome · NA · recruiting
NCT06392360 — Betaine, Exercise Performance, and Gut Permeability · NA · completed
NCT06204666 — Hemp Fiber Ingestion and Gut Permeability After Exercise · NA · completed
NCT05907135 — Beet Supplementation, Exercise, Inflammation · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03752125 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Appalachian State University
Last refreshed: 5 July 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03752125.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing