NCT03751514 (Periscope) is a NA clinical trial of Bordetella Pertussis B1917 in Whooping Cough, sponsored by University of Southampton.

Who is sponsoring NCT03751514?

NCT03751514 is sponsored by University of Southampton.

What drugs are being tested in NCT03751514?

Interventions in NCT03751514: Bordetella Pertussis B1917, Azithromycin 500 mg, Sterile Saline.

What condition does NCT03751514 study?

NCT03751514 studies Whooping Cough.

Is NCT03751514 still recruiting?

NCT03751514 is currently status unknown. Last updated 27 February 2020.

Last reviewed 2020-02-27 · How we verify

NCT03751514: Periscope

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Bordetella Pertussis Colonisation Challenge Study

Status unknown NA Last updated 27 February 2020

What this trial tests

NA trial testing Bordetella Pertussis B1917 in Whooping Cough in 80 participants. Status unknown.

Timeline

22 May 2017

Primary endpoint
2 February 2021

2 February 2021

Quick facts

Lead sponsor	University of Southampton
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	non randomized
Design	single group
Masking	none
Primary purpose	other
Enrollment	80
Start date	22 May 2017
Primary completion	2 February 2021
Estimated completion	2 February 2021
Sites	1 location across United Kingdom

Drugs / interventions tested

Bordetella Pertussis B1917 — full drug profile →
Azithromycin 500 mg — full drug profile →
Sterile Saline — full drug profile →

Conditions studied

Whooping Cough — all drugs for Whooping Cough →

Sponsor

University of Southampton

Who can join

Adults 18 to 45, any sex, with Whooping Cough. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a prospective controlled human challenge study consisting of two phases; Phase A: Development of a B. pertussis human challenge model; pilot to establish the standard inoculum Phase B: Development of a modified B. pertussis human challenge model

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Controlled Human Infection With Bordetella pertussis Induces Asymptomatic, Immunizing Colonization.
de Graaf H, Ibrahim M, Hill AR, Gbesemete D, et al · · 2020 · cited 68× · PMID 31562530 · DOI 10.1093/cid/ciz840
Distinct early cellular kinetics in participants protected against colonization upon Bordetella pertussis challenge.
Diks AM, de Graaf H, Teodosio C, Groenland RJ, et al · · 2023 · cited 14× · PMID 36649086 · DOI 10.1172/jci163121
Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination.
van Schuppen E, Fröberg J, Venkatasubramanian PB, Versteegen P, et al · · 2022 · cited 12× · PMID 36460655 · DOI 10.1038/s41467-022-35165-w
A qPCR assay for Bordetella pertussis cells that enumerates both live and dead bacteria.
Ramkissoon S, MacArthur I, Ibrahim M, de Graaf H, et al · · 2020 · cited 4× · PMID 32353041 · DOI 10.1371/journal.pone.0232334
Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study.
de Graaf H, Gbesemete DF, Hill AR, Fröberg J, et al · · 2026 · PMID 41887240 · DOI 10.1016/j.lanmic.2025.101313

Verify or expand the search:

Other recruiting trials for Whooping Cough

Currently open trials in the same condition.

NCT05091619 — A Phase 3 Study of BIBP Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed · Phase 3 · active not recruiting

Other University of Southampton trials

Trials by the same sponsor.

NCT07531277 — Developing Resource Interventions for Healthcare Professionals and Patients to Improve Knowledge About Fertility in Prim · NA · not yet recruiting
NCT06923943 — Predicting Nurse Staffing Requirements From Routinely Collected Data · active not recruiting
NCT06692959 — A Phase II Trial of Neoadjuvant PD-1 Vaccine PD1-Vaxx in Operable MSI High Colorectal Cancer · Phase 2 · recruiting
NCT06815120 — A Novel Ureteric Stent in Kidney Stone Patients and Oncology Patients Compared to a Conventional JJ Stent · NA · not yet recruiting
NCT06566157 — PROMOTE: The Effect of a Six Week Prebiotic Supplementation on Wellbeing of Young Adults. · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03751514 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Southampton
Last refreshed: 27 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03751514.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing