Last reviewed · How we verify
NCT03749863
Serial Platelet-Rich Plasma Injections for Vocal Fold Atrophy, Scar, and/or Sulcus Vocalis
NA trial testing Serial PRP injections in Presbylarynx in 14 participants. Completed in 30 September 2022.
30 September 2022
Quick facts
| Lead sponsor | University of Southern California |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 14 |
| Start date | 18 February 2020 |
| Primary completion | 30 September 2022 |
| Estimated completion | 30 September 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Serial PRP injections
Conditions studied
- Presbylarynx — all drugs for Presbylarynx →
- Atrophy; Larynx — all drugs for Atrophy; Larynx →
- Dysphonia — all drugs for Dysphonia →
- Vocal Cord Atrophy — all drugs for Vocal Cord Atrophy →
Sponsor
University of Southern California
Who can join
18 and older, any sex, with Presbylarynx or Atrophy; Larynx. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will investigate the safety and efficacy of four serial monthly vocal fold injections of platelet-rich plasma to treat dysphonia secondary to vocal fold atrophy, scar, and/or sulcus vocalis with glottal insufficiency
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Genipin cross-linked gelatin hydrogel for encapsulating wharton jelly mesenchymal stem cells and basic fibroblast growth factor delivery in vocal fold regeneration.
Wan-Chiew N, Baki MM, Lokanathan Y, Fauzi MB, et al · · 2024 · cited 6× · PMID 39703693 · DOI 10.3389/fcell.2024.1489901 -
Tissue Engineering as a Promising Treatment for Glottic Insufficiency: A Review on Biomolecules and Cell-Laden Hydrogel.
Ng WC, Lokanathan Y, Baki MM, Fauzi MB, et al · · 2022 · cited 3× · PMID 36551838 · DOI 10.3390/biomedicines10123082
Verify or expand the search:
- PubMed search for NCT03749863
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Presbylarynx
Currently open trials in the same condition.
- NCT03702322 — Improving Voice Production for Adults With Age-related Dysphonia · NA · active not recruiting
Other University of Southern California trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03749863 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Southern California
- Last refreshed: 10 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03749863.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing