NCT03746691 is a Phase 4 clinical trial of Citalopram HCl in Gastro Esophageal Reflux, sponsored by Universitaire Ziekenhuizen KU Leuven.

Who is sponsoring NCT03746691?

NCT03746691 is sponsored by Universitaire Ziekenhuizen KU Leuven.

What drugs are being tested in NCT03746691?

Interventions in NCT03746691: Citalopram HCl, Placebos.

What condition does NCT03746691 study?

NCT03746691 studies Gastro Esophageal Reflux.

Is NCT03746691 still recruiting?

NCT03746691 is currently completed. Last updated 20 November 2018.

Last reviewed 2018-11-20 · How we verify

NCT03746691

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Citalopram on Reflux Episodes in Healthy Volunteers

Completed Phase 4 Last updated 20 November 2018

What this trial tests

Phase 4 trial testing Citalopram HCl in Gastro Esophageal Reflux in 19 participants. Completed in 31 July 2017.

Timeline

1 February 2017

Primary endpoint
31 July 2017

31 July 2017

Quick facts

Lead sponsor	Universitaire Ziekenhuizen KU Leuven
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	19
Start date	1 February 2017
Primary completion	31 July 2017
Estimated completion	31 July 2017
Sites	1 location across Belgium

Drugs / interventions tested

Citalopram HCl — full drug profile →
Placebos — full drug profile →

Conditions studied

Gastro Esophageal Reflux — all drugs for Gastro Esophageal Reflux →

Sponsor

Universitaire Ziekenhuizen KU Leuven — full company profile →

Who can join

Adults 18 to 65, any sex, with Gastro Esophageal Reflux. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Citalopram is sometimes used in the treatment for gastro-esophageal reflux disease, however, there are no empirical data to support this. The investigators would like to know if citalopram has an effect on the lower esophageal sphincter pressure, transient lower esophageal sphincter relaxations and reflux episodes. The investigators will investigate this by performing high resolution impedance manometry in healthy volunteers before and after a solid meal. This will be compared to placebo, in a cross-over, randomized, double-blind condition.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Gastro Esophageal Reflux

Currently open trials in the same condition.

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NCT05455359 — Gastrointestinal Dysmotility on Aspiration Risk · Phase 4 · recruiting
NCT07131397 — The Effect of Inspiratory Muscle Training in People With Gastroesophageal Reflux Disease · NA · recruiting
NCT06564558 — The Effect of Postural Correction On Gastroesophageal Reflux Disease · NA · recruiting
NCT05570448 — Anti-Reflux Endoscopic TX Using APC (AREA) in GERD Patients: (The AREA Study) · NA · recruiting

Other Universitaire Ziekenhuizen KU Leuven trials

Trials by the same sponsor.

NCT06831955 — LifEStyle Intervention to Enhance Efficacy of Neoadjuvant Therapy in Patients With Triple Negative Breast Cancer · Phase 2 · recruiting
NCT07356505 — Efficacy and Safety of Micra AV2 Transcatheter Pacing System · NA · recruiting
NCT07286968 — Gastro-Intestinal Digestion and Physiology After Bariatric Surgery · recruiting
NCT06962137 — Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer · Phase 2 · recruiting
NCT07270536 — Accelerated Pacing and Cardiac Filling Pressures During Exercise in Patients With Heart Failure With Preserved Ejection · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03746691 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universitaire Ziekenhuizen KU Leuven
Last refreshed: 20 November 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03746691.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing