NCT03742817

Effects of e-Cigarettes on Perceptions and Behavior

Completed NA Last updated 11 July 2023

What this trial tests

NA trial testing e-Cigarette in Electronic Cigarettes in 45 participants. Completed in 1 March 2020.

Timeline

1 February 2019

Primary endpoint
1 March 2020

1 March 2020

Quick facts

Lead sponsor	University of Southern California
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	other
Enrollment	45
Start date	1 February 2019
Primary completion	1 March 2020
Estimated completion	1 March 2020
Sites	1 location across United States

Drugs / interventions tested

• e-Cigarette — full drug profile →

Conditions studied

• Electronic Cigarettes — all drugs for Electronic Cigarettes →

Sponsor

University of Southern California

Who can join

21 and older, any sex, with Electronic Cigarettes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project will assess the ways in which e-cigarette product diversity impacts the user experience to inform potential regulations by identifying product characteristics that may: (1) put young adults at risk for tobacco product use; and (2) facilitate adult smokers switching to e-cigarettes. There are three primary objectives to the study: (1) Determine which dimensions of e-cigarette product diversity differentially affect product appeal across young adult e-cigarette users and middle-age/older adult smokers with an interest in, but no significant experience with, e-cigarettes; (2) Determine which dimensions of e-cigarette product diversity differentially affect abuse liability in young adult e-cigarette users and the ability to resist smoking in adult smokers with an interest in, but no significant experience with, e-cigarettes; (3) Determine the affect of product characteristics on e-cigarette nicotine delivery profile. For Aim 1, young adult vapers (N=200) and adult smokers (N=200) will attend one laboratory session in which they will self-administer e-cigarette products varied according to within-subject e-cigarette factors (e.g., flavor, pg/vg ratio). For Aim 2, young adults vapers (N=360) and adult smokers (N=360) will administer an e-cigarette product and complete behavioral economic tasks that test the participant's choice of earning money to delay initiation and continued use of: (1) The sampled e-cigarette product (abuse liability; young adult vapers); or (2) Their own brand cigarettes (ability to resist smoking; adult current smokers). A pilot study will establish device and e-liquid parameters (e.g., nicotine concentration) to be used for all aims.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Dose-response effects of two nicotine salt formulations on electronic cigarette appeal and sensory attributes.
   Han DH, Wong M, Peraza N, Vogel EA, et al · · 2023 · cited 15× · PMID 36593119 · DOI 10.1136/tc-2022-057553
2. Effects of a fruit-ice combination flavor on appeal and sensory experience of vaping and moderation by preexisting e-cigarette flavor preference.
   Han DH, Peraza N, Jafarzadeh NS, Mason TB, et al · · 2024 · cited 1× · PMID 39207401 · DOI 10.1037/pha0000731