NCT03738319

Non-coding RNA in the Exosome of the Epithelia Ovarian Cancer

Status unknown Last updated 14 November 2018

What this trial tests

trial testing Sequencing of miRNA/lncRNA in High Grade Serous Carcinoma in 160 participants. Status unknown.

Timeline

10 November 2018

Primary endpoint
23 November 2019

23 November 2019

Quick facts

Lead sponsor	Lei Li
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	160
Start date	10 November 2018
Primary completion	23 November 2019
Estimated completion	23 November 2019
Sites	1 location across China

Drugs / interventions tested

• Sequencing of miRNA/lncRNA

Conditions studied

• High Grade Serous Carcinoma — all drugs for High Grade Serous Carcinoma →
• Ovarian Cancer — all drugs for Ovarian Cancer →
• Exosomes — all drugs for Exosomes →
• Prognosis — all drugs for Prognosis →

Sponsor

Lei Li — full company profile →

Who can join

18 and older, female only, with High Grade Serous Carcinoma or Ovarian Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to analyze the expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with high grade serous ovarian cancer (HGSOC) and benign gynecologic diseases. The candidate miRNA/lncRNA will be validated as biomarker for the detection and prognosis of HGSOC.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. The Role of Non-coding RNAs in Oncology.
   Slack FJ, Chinnaiyan AM. · · 2019 · cited 1219× · PMID 31730848 · DOI 10.1016/j.cell.2019.10.017
2. Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development.
   Kok VC, Yu CC. · · 2020 · cited 318× · PMID 33116515 · DOI 10.2147/ijn.s272378
3. Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications.
   Huda MN, Nafiujjaman M, Deaguero IG, Okonkwo J, et al · · 2021 · cited 160× · PMID 33988964 · DOI 10.1021/acsbiomaterials.1c00217
4. Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications.
   Rahbarghazi R, Jabbari N, Sani NA, Asghari R, et al · · 2019 · cited 160× · PMID 31291956 · DOI 10.1186/s12964-019-0390-y
5. Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications.
   He G, Peng X, Wei S, Yang S, et al · · 2022 · cited 147× · PMID 35039054 · DOI 10.1186/s12943-021-01440-5
6. The Role of Exo-miRNAs in Cancer: A Focus on Therapeutic and Diagnostic Applications.
   Ingenito F, Roscigno G, Affinito A, Nuzzo S, et al · · 2019 · cited 120× · PMID 31546654 · DOI 10.3390/ijms20194687
7. Mechanisms of Long Non-Coding RNAs in Cancers and Their Dynamic Regulations.
   Zhang XZ, Liu H, Chen SR. · · 2020 · cited 109× · PMID 32429086 · DOI 10.3390/cancers12051245
8. Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells.
   Salimi L, Akbari A, Jabbari N, Mojarad B, et al · · 2020 · cited 102× · PMID 32426106 · DOI 10.1186/s13578-020-00426-y