Last reviewed · How we verify
NCT03735186
Exercise and Coronary Heart Disease Risk Markers in Male Smokers and Non-Smokers
NA trial testing Exercise in Cigarette Smoking in 24 participants. Completed in 2 October 2018.
2 October 2018
Quick facts
| Lead sponsor | Loughborough University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 24 |
| Start date | 4 August 2017 |
| Primary completion | 2 October 2018 |
| Estimated completion | 2 October 2018 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Exercise
Conditions studied
- Cigarette Smoking — all drugs for Cigarette Smoking →
- Coronary Heart Disease — all drugs for Coronary Heart Disease →
- Cardiovascular Risk Factor — all drugs for Cardiovascular Risk Factor →
- Insulin Resistance — all drugs for Insulin Resistance →
Sponsor
Loughborough University
Who can join
Adults 20 to 45, male only, with Cigarette Smoking or Coronary Heart Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The present study will investigate the effect of acute exercise on fasting and postprandial risk markers for coronary heart disease (CHD) in healthy male cigarette smokers and non-smokers. Participants will complete two, 2-day trials in a random crossover design separated by an interval of at least 1 week. On day 1, participants will rest (control) or complete 60 minute of treadmill exercise at 60% of maximum oxygen uptake (exercise). On day 2, participants will rest and consume two high fat meals (breakfast and lunch) over an 8-h period during which 13 venous blood samples and nine blood pressure measurements will be taken at pre-determined intervals. It is hypothesised that men who smoke cigarettes will exhibit impaired fasting and postprandial metabolic risk markers compared to non-smokers, but a single bout of exercise will be equally, if not more, efficacious for improving the CHD risk factor profile in smokers than non-smokers.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial.
Alotaibi TF, Thackray AE, Roberts MJ, Alanazi TM, et al · · 2021 · cited 7× · PMID 33196606 · DOI 10.1249/mss.0000000000002560
Verify or expand the search:
- PubMed search for NCT03735186
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exercise
Trials testing the same drug.
- NCT06231069 — Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults · NA · withdrawn
- NCT07007858 — Effects of High-Velocity Passive Stretch on Spasticity, Function, and Muscle Structure in Spastic CP Children · NA · enrolling by invitation
- NCT07589725 — Mulligan Mobilization in Lateral Elbow Tendinopathy · NA · not yet recruiting
- NCT07524400 — Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease · NA · recruiting
- NCT06627569 — Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans · NA · not yet recruiting
Other recruiting trials for Cigarette Smoking
Currently open trials in the same condition.
- NCT07161050 — Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing · NA · recruiting
- NCT07014124 — Smoking Cessation for Fathers of Sick Children · NA · recruiting
- NCT06678789 — Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches · NA · recruiting
- NCT06609083 — Effect of Cannabis on Cigarette Use Behavior · Phase 1 · recruiting
- NCT05587361 — Beta-Adrenergic Modulation of Drug Cue Reactivity · Phase 4 · recruiting
Other Loughborough University trials
Trials by the same sponsor.
- NCT07510113 — Probiotic Study in Alcohol Recovery · NA · active not recruiting
- NCT07504952 — Investigating the Impact of Probiotics on Wellbeing in a Community · NA · completed
- NCT06682897 — Simplified Tai Chi Exercises to Improve Function in People With Chronic Ankle Instability · NA · completed
- NCT06669702 — EXercise Therapy in Axial SpA, Inflammation and Biologic Therapy (ExTASI-B) · NA · recruiting
- NCT06849050 — The Influence of Acute Continuous Exercise and Adiposity on Appetite Hormones and Neural Correlates of Visual Food Cues · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03735186 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Loughborough University
- Last refreshed: 9 November 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03735186.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing