Last reviewed · How we verify
NCT03732599
Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior Lamellar Keratoplaty (IE-DALK)
NA trial testing Standard Deep Anterior Keratoplasty (S-DALK) in DALK Corneal Transplant in 100 participants. Status unknown.
31 December 2019
Quick facts
| Lead sponsor | University of Toronto |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 8 April 2015 |
| Primary completion | 31 December 2019 |
| Estimated completion | 31 May 2021 |
Drugs / interventions tested
- Standard Deep Anterior Keratoplasty (S-DALK)
- IE-DALK (femtosecond)
Conditions studied
- DALK Corneal Transplant — all drugs for DALK Corneal Transplant →
- Keratoconus — all drugs for Keratoconus →
- Scar — all drugs for Scar →
Sponsor
University of Toronto
Who can join
Adults 18 to 70, any sex, with DALK Corneal Transplant or Keratoconus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A prospective comparison between standard deep anterior lamellar keratoplasty (S-DALK) performed manually using a blade (trephine) and femtosecond laser-enabled deep anterior lamellar keratoplasty (IE DALK), where incisions are performed using the femtosecond laser.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Deep anterior lamellar keratoplasty for keratoconus: Elements for success.
Pellegrini M, Yu AC, Busin M. · · 2022 · cited 7× · PMID 35971490 · DOI 10.4103/sjopt.sjopt_100_21 -
A randomized controlled trial comparing femtosecond-enabled deep anterior lamellar keratoplasty and standard deep anterior lamellar keratoplasty (FEDS Study).
Sorkin N, Hatch W, Mimouni M, Chew HF, et al · · 2023 · cited 2× · PMID 36693916 · DOI 10.1038/s41433-023-02387-1
Verify or expand the search:
- PubMed search for NCT03732599
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03732599 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Toronto
- Last refreshed: 27 November 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03732599.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing