NCT03731624

Diadenosine Polyphosphates and Mucin Associated With Ocular Surface Disorders

Status unknown Last updated 6 November 2018

What this trial tests

trial in Superior Limbic Keratoconjunctivitis in 50 participants. Status unknown.

Timeline

1 January 2018

Primary endpoint
31 December 2020

31 December 2023

Quick facts

Lead sponsor	Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	50
Start date	1 January 2018
Primary completion	31 December 2020
Estimated completion	31 December 2023
Sites	1 location across Taiwan

Conditions studied

• Superior Limbic Keratoconjunctivitis — all drugs for Superior Limbic Keratoconjunctivitis →
• Dry Eye Syndromes — all drugs for Dry Eye Syndromes →
• Graft Vs Host Disease — all drugs for Graft Vs Host Disease →

Sponsor

Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

Who can join

Adults 18 to 99, any sex, with Superior Limbic Keratoconjunctivitis or Dry Eye Syndromes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Dry eye disease, ocular graft-versus-host disease (GVHD), and superior limbic keratoconjunctivitis (SLK) are all ocular surface disorders which mostly involve the outer surface of the eye. Many of the ocular surface disorders may result from or be aggravated by the mechanical stress from eyelid blinking. Specifically, SLK is an inflammatory ocular surface disorder characterizing by redundant superior bulbar conjunctiva. Since redundant superior bulbar conjunctiva can cause a significant mechanical force during eyelid blinking, we found that conjunctival resection with Tenon's capsule excision is helpful in relieving the symptoms of SLK patients. Therapeutic contact lens, protecting the ocular surface from the microtrauma between eyelid and ocular surface, is also an effective treatment for severe dry eye disease, ocular GVHD, and SLK. Although shearing force/mechanical stress has been studied in many different tissues and disease entities, the impact of shearing force over ocular surface is still unclear.

While the importance of mechanical stress in ocular surface disorder has been reported, the specific molecule involving the pathogenesis is still unknown. Diadenosine polyphosphates are a family of dinucleotides. They can enhance tear secretion and increase corneal wound healing rate from previous reports. Shear-stress stimuli was also noted to be able to induce diadenosine polyphosphates releasing from human corneal epithelium. In addition, mucin, one of the three components of tear film, has been greatly emphasized in the pathogenesis of dry eye disease. There are also some reports about the shearing force compensating the mucin contents in the inflammatory lung/bowel diseases. If diadenosine polyphosphates or mucin indeed play a role in mechanical stress-related ocular surface disorders, it will be a promising therapeutic targeting in the future.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.