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NCT03729973
Comparing Efficacy Preoperative Nebulized: Ketamine , Mgspo4 ,and Lidocaine In Attenuating Endotracheal Sore Throat
Phase 3 trial testing Ketamine in Sore Throat in 100 participants. Completed in 1 March 2019.
1 January 2019
Quick facts
| Lead sponsor | Zagazig University |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 100 |
| Start date | 15 November 2018 |
| Primary completion | 1 January 2019 |
| Estimated completion | 1 March 2019 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Ketamine (ketamine) — full drug profile →
- Magnesium Sulfate — full drug profile →
- Lidocaine
- Normal saline
Conditions studied
- Sore Throat — all drugs for Sore Throat →
Sponsor
Zagazig University
Who can join
Adults 21 to 45, any sex, with Sore Throat. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
One of the most common complications after endotracheal intubation is sore throat Lidocaine jelly or spray, preoperative gargles with licorice or ketamine or I.V steroids used for prophylaxis against POST are expensive ,and having much more side effects,but nebulized lidocaine is easily found with decreasing cost ,easily administered ,acts immediately with short duration ,minimal side effects ,and no term residual side effects. Nebulized ketamine was found to have a protective effect on allergen-induced airway inflammatory injury , high airway reactivity ,and decreasing postoperative sore throat (POST) incidence . Magnesium sulfate is similar to ketamine in blocking the N-methyl-D-aspartate receptors.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03729973
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other recruiting trials for Sore Throat
Currently open trials in the same condition.
- NCT07486544 — Soaked Pharyngeal Packing Agents in Septoplasty · Phase 3 · recruiting
- NCT07287293 — Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General Anesthesia · NA · recruiting
- NCT07517926 — Chewing Gum and Cold Gargle on Post-Bronchoscopy Symptoms · NA · recruiting
- NCT06967896 — Different Models of Tracheal Catheters Are Used for Female Thyroid Glands · recruiting
Other Zagazig University trials
Trials by the same sponsor.
- NCT07423676 — Comparison Between Two Drugs in Sedation of Upper GI Endoscopy · not yet recruiting
- NCT07418307 — Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block · NA · not yet recruiting
- NCT07435025 — Surgery for Obstructed Gastric Carcinoma · NA · active not recruiting
- NCT07330375 — Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia · Phase 3 · not yet recruiting
- NCT07309731 — Impact OF Cooled Versus Thermal Radiofrequency Denervation In Management Of Chronic Lumber Facet Joint Pain · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03729973 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zagazig University
- Last refreshed: 19 March 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03729973.
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