NCT03728998 is a NA clinical trial of Passive leg raise (PLR) in Sepsis, sponsored by Frisius Medisch Centrum.

Who is sponsoring NCT03728998?

NCT03728998 is sponsored by Frisius Medisch Centrum.

What drugs are being tested in NCT03728998?

Interventions in NCT03728998: Passive leg raise (PLR), Clearsight non-invasive hemodynamic monitoring system.

Is NCT03728998 still recruiting?

NCT03728998 is currently completed. Last updated 26 April 2019.

Last reviewed 2019-04-26 · How we verify

NCT03728998

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Non-invasive Measurement of CO in Patients With Uncomplicated Sepsis

Completed NA Last updated 26 April 2019

What this trial tests

NA trial testing Passive leg raise (PLR) in Sepsis in 31 participants. Completed in 23 March 2019.

Timeline

1 May 2018

Primary endpoint
23 March 2019

23 March 2019

Quick facts

Lead sponsor	Frisius Medisch Centrum
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	screening
Enrollment	31
Start date	1 May 2018
Primary completion	23 March 2019
Estimated completion	23 March 2019
Sites	1 location across Netherlands

Drugs / interventions tested

Passive leg raise (PLR)
Clearsight non-invasive hemodynamic monitoring system

Conditions studied

Sepsis — all drugs for Sepsis →

Sponsor

Frisius Medisch Centrum — full company profile →

Who can join

16 and older, any sex, with Sepsis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Little is known about the optimal fluid therapy of patients with uncomplicated sepsis. Most recommendations are extrapolated from studies performed in patients with septic shock. Therefore, it is unknown how effective our current fluid therapy is. Furthermore, current therapy is not tailored to individual needs. The aim of the current study is to investigate the added value of non-invasive measurements of (dynamic) circulatory parameters in the treatment of a convenience sample of sepsis patients presenting to the ED.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Non-invasive assessment of fluid responsiveness to guide fluid therapy in patients with sepsis in the emergency department: a prospective cohort study.
Koopmans NK, Stolmeijer R, Sijtsma BC, van Beest PA, et al · · 2021 · cited 8× · PMID 33888514 · DOI 10.1136/emermed-2020-209771

Verify or expand the search:

Other trials of Passive leg raise (PLR)

Trials testing the same drug.

NCT03736421 — Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emerg · terminated

Other recruiting trials for Sepsis

Currently open trials in the same condition.

NCT07507877 — Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness · recruiting
NCT07154615 — Assessing Immune Dysfunction in Sepsis · recruiting
NCT07419802 — OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study · recruiting
NCT07351344 — African Survey on Sepsis Knowledge (ASK) · recruiting
NCT07448805 — Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit · NA · recruiting

Other Frisius Medisch Centrum trials

Trials by the same sponsor.

NCT06249035 — Feasibility of TEE During Cardiac Arrest in Dutch Emergency Departments · NA · recruiting
NCT06558630 — ED Airway Management in the Netherlands. · recruiting
NCT06202729 — Focus on Experienced Anxiety Related to an Emergency Department Visit · completed
NCT05732363 — Evaluation of Different Methods to Measure Muscle Mass and Strength in a Population With Class II/III Obesity · completed
NCT06119711 — Micronutrient Levels and Nutritional Status in Critical Illness · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03728998 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Frisius Medisch Centrum
Last refreshed: 26 April 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03728998.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing