NCT03728868 is a NA clinical trial of High dose F. prausnitzii and D. piger in Healthy Individuals, sponsored by Sahlgrenska University Hospital.

Who is sponsoring NCT03728868?

NCT03728868 is sponsored by Sahlgrenska University Hospital.

What drugs are being tested in NCT03728868?

Interventions in NCT03728868: Placebo, High dose F. prausnitzii and D. piger, Low dose F. prausnitzii and D. piger.

What condition does NCT03728868 study?

NCT03728868 studies Healthy Individuals.

Is NCT03728868 still recruiting?

NCT03728868 is currently completed. Last updated 25 February 2020.

Last reviewed 2020-02-25 · How we verify

NCT03728868

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Tolerability and Risk of Adverse Events With a Probiotic Supplement

Completed NA Last updated 25 February 2020

What this trial tests

NA trial testing Placebo in Healthy Individuals in 50 participants. Completed in 31 May 2019.

Timeline

10 October 2018

Primary endpoint
31 May 2019

31 May 2019

Quick facts

Lead sponsor	Sahlgrenska University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	other
Enrollment	50
Start date	10 October 2018
Primary completion	31 May 2019
Estimated completion	31 May 2019
Sites	1 location across Sweden

Drugs / interventions tested

Placebo
High dose F. prausnitzii and D. piger
Low dose F. prausnitzii and D. piger

Conditions studied

Healthy Individuals — all drugs for Healthy Individuals →

Sponsor

Sahlgrenska University Hospital

Who can join

Adults 20 to 40, any sex, with Healthy Individuals. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The butyrate-producing bacterium Faecalibacterium prausnitzii is abundant in the human bowel and can make up to 5% of the gastrointestinal flora in healthy individuals. A reduced presence of it has been associated with an imbalance in the gastrointestinal flora of metabolic syndromes such as type 2 diabetes, fat liver, and in inflammatory bowel disease. The present double-blind, placebo-controlled, randomized study is designed to investigate if dietary supplementation with F.prausnitzii (combined with D. piger) once a day for 8 consecutive weeks is tolerated compared to placebo and if it can affect the metabolism in a positive way.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Synergy and oxygen adaptation for development of next-generation probiotics.
Khan MT, Dwibedi C, Sundh D, Pradhan M, et al · · 2023 · cited 115× · PMID 37532933 · DOI 10.1038/s41586-023-06378-w

Verify or expand the search:

Other recruiting trials for Healthy Individuals

Currently open trials in the same condition.

NCT07340385 — Physiological and Biochemical Responses to Blood Flow Restriction Training · recruiting
NCT07287306 — Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals · NA · recruiting
NCT07047300 — Effect of Heel Lift Insole on Kinematics and Kinetics of the Lower Limb and Lumbar Spine Among Healthy Individuals · recruiting
NCT06711614 — FIRE-Diet: Food as an Intervention to Reduce the Effects of Woodsmoke Exposure on Respiratory Health · NA · recruiting
NCT06428526 — Impact of Sensory Electrical Stimulation on Sensation and Tremor · NA · active not recruiting

Other Sahlgrenska University Hospital trials

Trials by the same sponsor.

NCT07491094 — Repeated Examinations for Typing Pulmonary Embolism · recruiting
NCT07524608 — Implementing an Evidence-based, Standardized Care Bundle Targeting Register Nurses and Anaesthesiologists, to Enhance Pa · not yet recruiting
NCT07498959 — Primary RPLND Versus Systemic Chemotherapy in Good-prognosis Metastatic Testicular Cancer · NA · recruiting
NCT06896578 — Latitude - Lateral Lymph Node Attitude Study · NA · not yet recruiting
NCT07035600 — Walking and Sitting Difficulties After Rectal Cancer Surgery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03728868 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Sahlgrenska University Hospital
Last refreshed: 25 February 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03728868.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing