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NCT03728803: NEMTRAIN
Inspiratory Muscle Training in Nemaline Myopathy
NA trial testing Threshold IMT, Philips Respironics, Murrysville, PA, USA in Nemaline Myopathy in 42 participants. Completed in 25 March 2021.
25 March 2021
Quick facts
| Lead sponsor | Radboud University Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 42 |
| Start date | 10 October 2018 |
| Primary completion | 25 March 2021 |
| Estimated completion | 25 March 2021 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Threshold IMT, Philips Respironics, Murrysville, PA, USA
Conditions studied
- Nemaline Myopathy — all drugs for Nemaline Myopathy →
- Inspiratory Muscle Training — all drugs for Inspiratory Muscle Training →
Sponsor
Radboud University Medical Center
Who can join
Adults 6 to 80, any sex, with Nemaline Myopathy or Inspiratory Muscle Training. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Nemaline myopathy is a rare congenital myopathy. Respiratory failure is the main cause of death in these patients. The primary objective of this study is to determine the effect of a 8-week inspiratory muscle training program on respiratory muscle function in nemaline myopathy patients. The secondary objective is to determine respiratory muscle function in nemaline myopathy patients and its correlation with clinical severity and general neuromuscular function. The nemaline myopathy patients will be included in the first phase for a clinical characterization. From this phase patients will be selected for the second phase, which is a controlled before-after trial of inspiratory muscle training. The primary outcome is the change in maximal inspiratory pressure (MIP) after active inspiratory muscle training
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Inspiratory Muscle Training in Nemaline Myopathy.
van Kleef ESB, Langer D, van Engelen BGM, Ottenheijm CAC, et al · · 2023 · cited 2× · PMID 37458044 · DOI 10.3233/jnd-221665
Verify or expand the search:
- PubMed search for NCT03728803
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Nemaline Myopathy
Currently open trials in the same condition.
- NCT07478172 — Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease · NA · recruiting
Other Radboud University Medical Center trials
Trials by the same sponsor.
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- NCT07530263 — Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA) · Phase 1 · not yet recruiting
- NCT07532577 — Intranasal Insulin to Prevent Intensive Care Unit Delirium · Phase 2, PHASE3 · not yet recruiting
- NCT07504172 — Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03728803 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
- Last refreshed: 5 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03728803.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing