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NCT03724838
Esomeprazole With Sildenafil Citrate in Women With Early-onset Preeclampsia
NA trial testing Esomeprazole with Sildenafil Citrate in Preeclampsia in 180 participants. Status unknown.
30 November 2021
Quick facts
| Lead sponsor | Aswan University Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 180 |
| Start date | 1 December 2018 |
| Primary completion | 30 November 2021 |
| Estimated completion | 1 January 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Esomeprazole with Sildenafil Citrate — full drug profile →
- Sildenafil Citrate (Sildenafil Citrate) — full drug profile →
- Placebo to Esomeprazole
- Placebo to Sildenafil Citrate — full drug profile →
Conditions studied
- Preeclampsia — all drugs for Preeclampsia →
Sponsor
Aswan University Hospital
Who can join
Adults 18 to 45, female only, with Preeclampsia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Previous studies have shown that expectant management of preeclampsia in the context of extreme prematurity may improve perinatal outcomes. Indeed, it has been estimated that for each additional day of pregnancy prolongation between 24 and 32 weeks of gestation, there is a nonlinear corresponding gain of 1% in fetal survival. In this study, we evaluate the use of Esomeprazole alone or with Sildenafil Citrate for the treatment of singleton pregnancies complicated by preeclampsia. We hypothesized that the potential increase in uteroplacental and fetoplacental blood flow with the use of Esomeprazole alone or with Sildenafil Citrate may be associated with pregnancy prolongation (the primary study outcome) and improved maternal and perinatal outcomes.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
New Ideas for the Prevention and Treatment of Preeclampsia and Their Molecular Inspirations.
Sakowicz A, Bralewska M, Rybak-Krzyszkowska M, Grzesiak M, et al · · 2023 · cited 28× · PMID 37569476 · DOI 10.3390/ijms241512100 -
Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis.
Hussain S, Singh A, Antony B, Klugarová J, et al · · 2022 · cited 6× · PMID 36012913 · DOI 10.3390/jcm11164675
Verify or expand the search:
- PubMed search for NCT03724838
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Preeclampsia
Currently open trials in the same condition.
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- NCT07282171 — A Study to Investigate the Safety, Pharmacodynamic and Pharmacokinetic Characteristics of CBP-4888 in Hospitalized Parti · Phase 1 · recruiting
- NCT07345845 — MR and Inflammation After Preeclampsia · EARLY_PHASE1 · active not recruiting
- NCT07041281 — Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories · Phase 2 · recruiting
Other Aswan University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03724838 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Aswan University Hospital
- Last refreshed: 10 January 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03724838.
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