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Influence of Nitric Oxide on Flow Mediated Dilation
Flow-mediated vasodilation (FMD) has become one of the most widely assessed parameter to analyze endothelial function. The peripheral endothelial function as assessed by FMD correlates with coronary artery endothelial function and moreover, impaired FMD has been revealed to be good predictor for cardiovascular events in patients beyond cardiovascular risk factors and in patients with coronary artery disease. This non-invasive technique measures the ability of the arteries to respond with endothelial release of vasoactive factors during reactive hyperemia. In this study the goal is to analyze in a clinical trial to what extend nitric oxide contribute to FMD by measuring FMD before and after blocking the release of nitric oxide. FMD is measured using a semi-automatic device named UNEX, recently developed in Japan. This semi-automatic ultrasound system represents a new development that overcomes the limitation of classic systems. The hypothesis of this study is that FMD response is mostly nitric oxide dependent. To prove this hypothesis, overall 20 healthy male volunteers are included in this study. Total duration of this study for each volunteer is 2-4 weeks with total 3 visits at the Clinical Research Unit (CRC) of the Department of Nephrology, University of Erlangen-Nuremberg. This study is important to better understand the mechanism of any kind of impaired FMD by cardiovascular risk factors and diseases and to better interpret impaired FMD assessed by UNEX.
Details
| Lead sponsor | University of Erlangen-Nürnberg Medical School |
|---|---|
| Status | COMPLETED |
| Enrolment | 20 |
| Start date | Wed Nov 14 2018 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sun Mar 31 2019 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- FMD - Flow Mediated Dilation
Countries
Germany