NCT03719521: CHIEDZA

Community Based Interventions to Improve HIV Outcomes in Youth: a Cluster Randomised Trial in Zimbabwe

Completed NA Last updated 27 January 2023

What this trial tests

NA trial testing Community-based package of integrated HIV, SRH and general health services in HIV Infection in 36,991 participants. Completed in 30 June 2022.

Timeline

1 April 2019

Primary endpoint
30 June 2022

30 June 2022

Quick facts

Lead sponsor	London School of Hygiene and Tropical Medicine
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	36,991
Start date	1 April 2019
Primary completion	30 June 2022
Estimated completion	30 June 2022
Sites	3 locations across Zimbabwe

Drugs / interventions tested

• Community-based package of integrated HIV, SRH and general health services

Conditions studied

• HIV Infection — all drugs for HIV Infection →

Sponsor

London School of Hygiene and Tropical Medicine

Who can join

Adults 16 to 24, any sex, with HIV Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A cluster randomised trial to determine the impact of an integrated community-based package of HIV services incorporating HIV testing, linkage to care and ongoing adherence support, combined with sexual and reproductive health (SRH) services and general health counselling for 16 to 24 year olds on population level HIV viral load in a high HIV prevalence setting.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Accuracy of measures for antiretroviral adherence in people living with HIV.
   Smith R, Villanueva G, Probyn K, Sguassero Y, et al · · 2022 · cited 34× · PMID 35871531 · DOI 10.1002/14651858.cd013080.pub2
2. Uptake of and factors associated with testing for sexually transmitted infections in community-based settings among youth in Zimbabwe: a mixed-methods study.
   Martin K, Olaru ID, Buwu N, Bandason T, et al · · 2021 · cited 32× · PMID 33417838 · DOI 10.1016/s2352-4642(20)30335-7
3. The impact of community-based integrated HIV and sexual and reproductive health services for youth on population-level HIV viral load and sexually transmitted infections in Zimbabwe: protocol for the CHIEDZA cluster-randomised trial.
   Dziva Chikwari C, Dauya E, Bandason T, Tembo M, et al · · 2022 · cited 27× · PMID 38162283 · DOI 10.12688/wellcomeopenres.17530.2
4. Reaching the second 90: the strategies for linkage to care and antiretroviral therapy initiation.
   Bunda BA, Bassett IV. · · 2019 · cited 25× · PMID 31408009 · DOI 10.1097/coh.0000000000000579
5. Putting youth at the centre: co-design of a community-based intervention to improve HIV outcomes among youth in Zimbabwe.
   Mackworth-Young CR, Dringus S, Dauya E, Dziva Chikwari C, et al · · 2022 · cited 23× · PMID 38264344 · DOI 10.12688/wellcomeopenres.17531.2
6. When healthcare providers are supportive, 'I'd rather not test alone': Exploring uptake and acceptability of HIV self-testing for youth in Zimbabwe - A mixed method study.
   Mavodza CV, Mackworth-Young CRS, Bandason T, Dauya E, et al · · 2021 · cited 19× · PMID 34569710 · DOI 10.1002/jia2.25815
7. Menstrual product choice and uptake among young women in Zimbabwe: a pilot study.
   Tembo M, Renju J, Weiss HA, Dauya E, et al · · 2020 · cited 18× · PMID 33292659 · DOI 10.1186/s40814-020-00728-5
8. "It was difficult to offer same day results": evaluation of community-based point-of-care testing for sexually transmitted infections among youth using the GeneXpert platform in Zimbabwe.
   Martin K, Dziva Chikwari C, Mackworth-Young CRS, Chisenga M, et al · · 2022 · cited 17× · PMID 35144602 · DOI 10.1186/s12913-022-07557-7