Who is sponsoring NCT03719417?

NCT03719417 is sponsored by University of Missouri-Columbia.

What drugs are being tested in NCT03719417?

Interventions in NCT03719417: Unicompartmental Biologic Arthroplasty, Extensive Biologic Arthroplasty.

What condition does NCT03719417 study?

NCT03719417 studies Knee Osteoarthritis, Post-traumatic Osteoarthritis.

Is NCT03719417 still recruiting?

NCT03719417 is currently completed. Last updated 2 November 2022.

Last reviewed 2022-11-02 · How we verify

NCT03719417

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Biologic Joint Replacement Strategy for Knee Trauma and Post-Traumatic Osteoarthritis

Completed NA Last updated 2 November 2022

What this trial tests

NA trial testing Unicompartmental Biologic Arthroplasty in Knee Osteoarthritis in 14 participants. Completed in 31 October 2022.

Timeline

1 December 2018

Primary endpoint
1 June 2022

31 October 2022

Quick facts

Lead sponsor	University of Missouri-Columbia
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	14
Start date	1 December 2018
Primary completion	1 June 2022
Estimated completion	31 October 2022
Sites	1 location across United States

Drugs / interventions tested

Unicompartmental Biologic Arthroplasty
Extensive Biologic Arthroplasty

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
Post-traumatic Osteoarthritis — all drugs for Post-traumatic Osteoarthritis →

Sponsor

University of Missouri-Columbia

Who can join

Adults 18 to 55, any sex, with Knee Osteoarthritis or Post-traumatic Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Participants will be enrolled in a prospective clinical trial to assess outcomes in 2 cohorts of patients undergoing unicompartmental versus more extensive biologic OCA transplantation of the knee using MOPSTM-preserved allografts (including menisci), anatomically-shaped allografts, autogenous bone marrow aspirate concentrate (BMC)-treated donor bone, and treatment-specific postoperative rehabilitation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Current Status of Clinical Trials on Biologics for Cartilage Repair and Osteoarthritis Treatment: An Analysis of ClinicalTrials.gov Data.
Zhang Z, Schon L. · · 2022 · cited 21× · PMID 35546280 · DOI 10.1177/19476035221093065

Verify or expand the search:

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other University of Missouri-Columbia trials

Trials by the same sponsor.

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NCT07067502 — Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations · NA · not yet recruiting
NCT07424079 — Metacognitive Strategy Training Intervention for Transition-Age Youth With Cerebral Palsy · NA · not yet recruiting
NCT07216196 — The Feasibility of a Remote Problem-Solving Intervention for Autistic Adolescents or Young Adults and a Caregiver · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03719417 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Missouri-Columbia
Last refreshed: 2 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03719417.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing