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NCT03714295: BACTERIB
Impact of Interdental Brushing on the Evolution of Supra-gingival Bacterial Flora (BACTERIB)
trial testing Use of interdental brushes in Healthy in 25 participants. Completed in 1 July 2015.
15 April 2015
Quick facts
| Lead sponsor | Claude Bernard University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 25 |
| Start date | 1 April 2015 |
| Primary completion | 15 April 2015 |
| Estimated completion | 1 July 2015 |
| Sites | 1 location across France |
Drugs / interventions tested
- Use of interdental brushes
Conditions studied
- Healthy — all drugs for Healthy →
Sponsor
Claude Bernard University
Who can join
Adults 18 to 35, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In France, two-thirds of adults over 35 years of age have at least a periodontal disease. The etiology is the accumulation of dental plaque, especially in interdental spaces. The cleaning of interdental spaces is particularly complex. This accumulation of dental plaque is at the origin of a modification of the bacterial flora in favor of periodontopathogenic bacteria. These pathogens can induce within the periodontal tissues an immune and inflammatory reaction that cause tissue degradation. The majority of studies focus on people over 30 years of age with gingivitis or periodontitis. However, young adults, in whom the initial or even reversible stages of periodontal disease are the most frequent, should be the preferred target of preventive measures for this pathology. The main objective of this study is to quantify, in healthy patients, the evolution of the supragingival bacterial flora, in the interdental spaces, following the daily passage of brushes with the adapted diameter and single passage. The secondary objective is to evaluate the qualitative change in the bacterial flora (proportions of periodontal bacteria / commensal bacteria) following the interdental cleaning.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Calibrated interdental brushing for the prevention of periodontal pathogens infection in young adults - a randomized controlled clinical trial.
Bourgeois D, Bravo M, Llodra JC, Inquimbert C, et al · · 2019 · cited 40× · PMID 31641199 · DOI 10.1038/s41598-019-51938-8
Verify or expand the search:
- PubMed search for NCT03714295
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Claude Bernard University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03714295 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Claude Bernard University
- Last refreshed: 22 October 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03714295.
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