NCT03709459 (Syphilaxis) is a clinical trial of Doxycycline in STIs Prevention, sponsored by Kirby Institute.

Who is sponsoring NCT03709459?

NCT03709459 is sponsored by Kirby Institute.

What drugs are being tested in NCT03709459?

Interventions in NCT03709459: Doxycycline.

What condition does NCT03709459 study?

NCT03709459 studies STIs Prevention.

Is NCT03709459 still recruiting?

NCT03709459 is currently status unknown. Last updated 5 October 2023.

Last reviewed 2023-10-05 · How we verify

NCT03709459: Syphilaxis

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of the Daily Doxycycline Pre-exposure Prophylaxis (PrEP) on the Incidence of Syphilis, Gonorrhoea and Chlamydia

Status unknown Last updated 5 October 2023

What this trial tests

trial testing Doxycycline in STIs Prevention in 100 participants. Status unknown.

Timeline

17 December 2019

Primary endpoint
17 July 2024

17 December 2024

Quick facts

Lead sponsor	Kirby Institute
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	100
Start date	17 December 2019
Primary completion	17 July 2024
Estimated completion	17 December 2024
Sites	4 locations across Australia

Drugs / interventions tested

Doxycycline (doxycycline) — full drug profile →

Conditions studied

STIs Prevention — all drugs for STIs Prevention →

Sponsor

Kirby Institute

Who can join

18 and older, male only, with STIs Prevention. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

1\. This study is a non-randomized observational cohort trial using before and after comparison to evaluate intervention 2. It would mimic the conditions that would occur outside a clinical trial. 2. After consent and enrolment, all procedures will be guided by the Australian STI Management Guidelines. 3\. All enrolling participants will be offered daily doxycycline 100mg 4. All participants will be invited to complete a survey in every 3 months time for 12 months dated from participation. 5\. All follow-up information will be collected through electronic data capture to allow accurate and timely analyses. 6\. Data collection will be from (i) medical records (ii) online self-completed questionnaire

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Non-conventional interventions to prevent gonorrhea or syphilis among men who have sex with men: A scoping review.
Tran J, Fairley CK, Bowesman H, Aung ET, et al · · 2022 · cited 2× · PMID 36203757 · DOI 10.3389/fmed.2022.952476

Verify or expand the search:

Other trials of Doxycycline

Trials testing the same drug.

NCT07306234 — Doxycycline vs. Macrolide for MRMP (DOMINO) · Phase 4 · not yet recruiting
NCT07230028 — Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. · Phase 4 · not yet recruiting
NCT07343635 — The Efficacy and Safety of Anti-inflammation Treatment (Hirudoid Introduction Followed by Yellow Light Therapy) Combined · NA · recruiting
NCT07164131 — Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lacta · Phase 4 · recruiting
NCT06915688 — A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations · NA · not yet recruiting

Other Kirby Institute trials

Trials by the same sponsor.

NCT07145736 — Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical · Phase 4 · recruiting
NCT06220370 — PATH Study: People With Injecting Related Infections: Assessing Treatment Outcomes for Those Who Are Hospitalised. · not yet recruiting
NCT05415267 — Immunosuppression and COVID-19 Boosters · Phase 3 · recruiting
NCT05144776 — Evaluation of Hepatitis B Virus (HBV) DNA Test As Point of Care Tool · completed
NCT04014179 — Enhancing Hepatitis C Testing and Treatment Among People Who Inject Drugs Attending Needle and Syringe Programs · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03709459 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Kirby Institute
Last refreshed: 5 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03709459.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing