Eligibility, any sex, with Adherence, Medication or Nonadherence, Medication. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Median Proportion of Days Covered (PDC) at 8-months Post-enrollmentPrimary· 8 months post-enrollment
Proportion of days covered (PDC) is a calculated value ranging from 0 to 1 where 1 indicates 100% adherence to medication and 0 indicates zero adherence to medication. It uses a patient's refill history to calculate the days' supply obtained over a time period (in days) divided by the time period (in days). It requires at least 2 refills.
Group
Value
95% CI
Patient-tailored Intervention
0.94
0.84 – 1.0
Usual Care
0.88
0.75 – 0.97
Median Proportion of Days Covered (PDC) at 6-months Post-enrollmentSecondary· 6 months post-enrollment
Proportion of days covered (PDC) is a calculated value ranging from 0 to 1 where 1 indicates 100% adherence to medication and 0 indicates zero adherence to medication. It uses a patient's refill history to calculate the days' supply obtained over a time period (in days) divided by the time period (in days). It requires at least 2 refills.
Group
Value
95% CI
Patient-tailored Intervention
0.95
0.84 – 1.00
Usual Care
0.90
0.76 – 0.98
Reasons for Nonadherence in the Intervention ArmSecondary· 35 months
Reasons for nonadherence were obtained from a combination of electronic health records and patient-reported reasons. Since only intervention patients were contacted during this study, only reasons from the intervention arm are reported. Reasons were collected for each patient starting on the date of enrollment until 8-months post-enrollment starting from the date the study began (May 2019) until the study was complete (April 2022).
Memory
Group
Value
95% CI
Intervention Arm
81
Unreachable for refill
Group
Value
95% CI
Intervention Arm
60
No known reason
Group
Value
95% CI
Intervention Arm
35
Unresponsive to refill requirements
Group
Value
95% CI
Intervention Arm
31
Clinical
Group
Value
95% CI
Intervention Arm
25
Social issues
Group
Value
95% CI
Intervention Arm
23
Health literacy
Group
Value
95% CI
Intervention Arm
19
Health system error
Group
Value
95% CI
Intervention Arm
15
Median Proportion of Days Covered (PDC) at 12-months Post-enrollmentSecondary· 12 months post-enrollment
Proportion of days covered (PDC) is a calculated value ranging from 0 to 1 where 1 indicates 100% adherence to medication and 0 indicates zero adherence to medication. It uses a patient's refill history to calculate the days' supply obtained over a time period (in days) divided by the time period (in days). It requires at least 2 refills.
Group
Value
95% CI
Patient-tailored Intervention
0.93
0.82 – 0.98
Usual Care
0.87
0.72 – 0.95
Sponsor's own description
Patients deemed nonadherent to their specialty medications will be randomized to receive 8 months of patient-tailored adherence interventions and follow up from a specialty pharmacist as needed or the standard of care. Medication adherence will be measured using proportion of days covered (PDC) at 8-months post-randomization to determine if the intervention improved specialty medication adherence.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
Last refreshed: 1 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03709277.