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NCT03708172
rTMS and Cognitive Training in Youth Depression
NA trial testing Repetitive Transcranial Magnetic Stimulation in Depression in 30 participants. Completed in 31 May 2019.
31 May 2019
Quick facts
| Lead sponsor | Centre for Addiction and Mental Health |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 1 August 2017 |
| Primary completion | 31 May 2019 |
| Estimated completion | 31 May 2019 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Repetitive Transcranial Magnetic Stimulation
- Cognitive Training
- sham Cognitive Training
Conditions studied
- Depression — all drugs for Depression →
Sponsor
Centre for Addiction and Mental Health — full company profile →
Who can join
Adults 16 to 24, any sex, with Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Youth depression is a highly prevalent disorder with tremendous personal and societal costs. Guideline supported treatments are limited in efficacy and associated with side effects. Novel, safe, and effective treatments are sorely needed. This study will examine the biological targets, and efficacy, of cognitive training in combination with repetitive transcranial magnetic stimulation (rTMS) in non-medicated, depressed youth. If positive, the investigators will have identified an effective, safe, and acceptable alternative treatment for a population with few treatment options. Identifying biological mechanisms of response will ultimately enable clinicians to tailor individual interventions for depressed youth.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Prefrontal Cortical Reactivity and Connectivity Markers Distinguish Youth Depression from Healthy Youth.
Dhami P, Atluri S, Lee JC, Knyahnytska Y, et al · · 2020 · cited 31× · PMID 32118262 · DOI 10.1093/cercor/bhaa004 -
Baseline markers of cortical excitation and inhibition predict response to theta burst stimulation treatment for youth depression.
Dhami P, Moreno S, Croarkin PE, Blumberger DM, et al · · 2023 · cited 9× · PMID 37925557 · DOI 10.1038/s41598-023-45107-1
Verify or expand the search:
- PubMed search for NCT03708172
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other recruiting trials for Depression
Currently open trials in the same condition.
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Other Centre for Addiction and Mental Health trials
Trials by the same sponsor.
- NCT07211438 — Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression · Phase 2 · not yet recruiting
- NCT07146633 — Efficacy of an EMDR App for PTSD and SUD · NA · recruiting
- NCT07228923 — Development and Evaluation of a Theory and Evidence-based Intervention to Reduce Hazardous Alcohol Consumption Among Tre · NA · not yet recruiting
- NCT07105449 — THC Titration of High-Potency Cannabis Concentrates · NA · not yet recruiting
- NCT06928935 — Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03708172 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre for Addiction and Mental Health
- Last refreshed: 25 October 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03708172.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing