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NCT03707249
Iron Status and Cardiopulmonary Physiology
NA trial testing Ferric Carboxymaltose Injectable Product in Iron-deficiency in 18 participants. Completed in 7 December 2017.
1 May 2016
Quick facts
| Lead sponsor | Royal Centre for Defence Medicine |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 18 |
| Start date | 19 January 2016 |
| Primary completion | 1 May 2016 |
| Estimated completion | 7 December 2017 |
Drugs / interventions tested
- Ferric Carboxymaltose Injectable Product — full drug profile →
- Normal Saline 0.9% Infusion Solution Bag — full drug profile →
Conditions studied
- Iron-deficiency — all drugs for Iron-deficiency →
- Ventricular Function — all drugs for Ventricular Function →
- Pulmonary Vascular Resistance Abnormality — all drugs for Pulmonary Vascular Resistance Abnormality →
- Altitude Hypoxia — all drugs for Altitude Hypoxia →
Sponsor
Royal Centre for Defence Medicine — full company profile →
Who can join
Adults 18 to 55, any sex, with Iron-deficiency or Ventricular Function. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study involved human volunteers undertaking a high-altitude expedition. It assessed changes in physiological parameters of relevance to high-altitude cardiopulmonary physiology. Participants included a subgroup of those taking part in an existing adventurous training expedition and were randomised in a 1:1 fashion to receive either intravenous iron or normal saline several weeks prior to departure. During the expedition, participants were investigated by means of transthoracic echocardiography, peripheral oxygen saturation measurement and heart rate monitoring and through the drawing of venous blood samples. Bloods were later analysed for markers of iron status.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Iron bioavailability and cardiopulmonary function during ascent to very high altitude.
Holdsworth DA, Frise MC, Bakker-Dyos J, Boos C, et al · · 2020 · cited 15× · PMID 32430412 · DOI 10.1183/13993003.02285-2019
Verify or expand the search:
- PubMed search for NCT03707249
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
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Currently open trials in the same condition.
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- NCT05340465 — Darbe Plus IV Iron to Decrease Transfusions While Maintaining Iron Sufficiency in Preterm Infants · Phase 2 · recruiting
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Other Royal Centre for Defence Medicine trials
Trials by the same sponsor.
- NCT04476680 — Influence of Military Preventive Policy for reCruit Training on COVID-19 Seroconversion · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03707249 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Royal Centre for Defence Medicine
- Last refreshed: 18 October 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03707249.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing