NCT03705273 is a Phase 4 clinical trial of Dexamethasone IV for PO in Asthma, sponsored by Vanderbilt University Medical Center.

Who is sponsoring NCT03705273?

NCT03705273 is sponsored by Vanderbilt University Medical Center.

What drugs are being tested in NCT03705273?

Interventions in NCT03705273: Dexamethasone IV for PO, Dexamethasone crushed tablets.

What condition does NCT03705273 study?

NCT03705273 studies Asthma, Croup.

Is NCT03705273 still recruiting?

NCT03705273 is currently terminated. Last updated 8 November 2021.

Are results published for NCT03705273?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2021-11-08 · How we verify

NCT03705273

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup

Terminated Phase 4 Results posted Last updated 8 November 2021

What this trial tests

Phase 4 trial testing Dexamethasone IV for PO in Asthma in 40 participants. Terminated before completion.

Timeline

23 October 2018

Primary endpoint
2 October 2020

2 October 2020

Quick facts

Lead sponsor	Vanderbilt University Medical Center
Phase	Phase 4
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	40
Start date	23 October 2018
Primary completion	2 October 2020
Estimated completion	2 October 2020
Sites	1 location across United States

Drugs / interventions tested

Dexamethasone IV for PO — full drug profile →
Dexamethasone crushed tablets — full drug profile →

Conditions studied

Asthma — all drugs for Asthma →
Croup — all drugs for Croup →

Sponsor

Vanderbilt University Medical Center

Who can join

Adults 1 to 7, any sex, with Asthma or Croup. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Participants With Nausea Primary · 1 hour

Presence of nausea after medication administration (yes/no) measured by participant self-report

Group	Value	95% CI
Dexamethasone Tablets	3
Dexamethasone IV for PO	0

Number of Participants Requiring Second Dose of Dexamethasone Secondary · 1 hour

Reason for patient needing a second dose of dexamethasone; such as spit dose up or vomiting dose

Group	Value	95% CI
Dexamethasone Tablets	0
Dexamethasone IV for PO	0

Sponsor's own description

Study of the palatability and acceptability of dexamethasone oral tablets crushed and placed in apple sauce or pudding in comparison with the IV solution mixed with sugar syrup and given orally. It is hypothesized that dexamethasone tablets crushed and administered in apple sauce or pudding will be more palatable and acceptable for pediatric patients receiving dexamethasone for an acute asthma exacerbation or croup.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Asthma

Currently open trials in the same condition.

NCT07525375 — A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared t · Phase 2 · recruiting
NCT07536256 — Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being · NA · recruiting
NCT07556159 — A Study Evaluating Disease Characteristics and Outcomes in Participants With Asthma in Routine Clinical Practice · recruiting
NCT07282886 — VENTURI (VENTilation Using Respiratory Imaging) · Phase 2 · recruiting
NCT07433569 — A Study to Investigate How Budesonide and Formoterol Move Through the Body (Pharmacokinetics) When Delivered With Differ · Phase 1 · recruiting

Other Vanderbilt University Medical Center trials

Trials by the same sponsor.

NCT07005037 — Swallowing Impairments in ICU Survivors and Community-Dwelling Adults · not yet recruiting
NCT07527273 — Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) · NA · not yet recruiting
NCT07295288 — Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis · Phase 4 · not yet recruiting
NCT07431541 — Topical Carboxytherapy Paste Following Microneedling · Phase 1, PHASE2 · not yet recruiting
NCT07224711 — The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03705273 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
Last refreshed: 8 November 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03705273.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing