NCT03701971: PRURI-MUSIC

Study Evaluating the Benefit of Music Therapy on Pruritus in Patients With Pruritic Dermatitis

Completed NA Last updated 28 August 2019

What this trial tests

NA trial testing evaluation of the intensity of pruritus in Pruritus in 50 participants. Completed in 19 April 2019.

Timeline

8 November 2018

Primary endpoint
19 April 2019

19 April 2019

Quick facts

Lead sponsor	University Hospital, Brest
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	50
Start date	8 November 2018
Primary completion	19 April 2019
Estimated completion	19 April 2019
Sites	1 location across France

Drugs / interventions tested

• evaluation of the intensity of pruritus

Conditions studied

• Pruritus — all drugs for Pruritus →

Sponsor

University Hospital, Brest

Who can join

18 and older, any sex, with Pruritus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Many clinical studies have shown the benefit of music therapy in various pathologies, including pain, and it is now established that the latter has a complementary therapeutic interest. Its most frequently identified indications are the fight against acute or chronic pains, the reduction of anxiety, depression and stress, as well as memory disorders such as Alzheimer's disease.

The main modes of action of music therapy involve sensory, cognitive, psychological and behavioral processes that are also found in pruritus.

Pruritus is defined as "an uncomfortable sensation causing the need to scratch. It has similarities with pain but also differences: relief by heat / cold, scratching / withdrawal behavior, localization on the skin, semi-mucous / ubiquitous ... etc.

The pathophysiology also has similarities, pruritus is born at the dermal-epidermal junction at the level of specific cutaneous receptors then follows the classical pathways through a 1st neuron, then the dorsal horn of the spinal cord and a second neuron. At the cerebral level, there is no single center of pruritus but several motor and sensory areas involved.

The similarities suggest that music therapy may have an interest in the management of chronic pruritus, especially since classical treatments (antihistamines, topical corticosteroids) have only partial efficacy in some dermatoses

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effectiveness of a music intervention on pruritus: an open randomized prospective study.
   Demirtas S, Houssais C, Tanniou J, Misery L, et al · · 2020 · cited 11× · PMID 31838780 · DOI 10.1111/jdv.16149