NCT03699020

Acceptance and Commitment Therapy for Aging People Living With HIV in Chronic Pain

Completed NA Results posted Last updated 18 November 2023

What this trial tests

NA trial testing Acceptance and Commitment Therapy (ACT) in HIV/AIDS in 13 participants. Completed in 30 June 2022.

Timeline

7 January 2019

Primary endpoint
30 June 2022

30 June 2022

Quick facts

Lead sponsor	University of California, San Diego
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	13
Start date	7 January 2019
Primary completion	30 June 2022
Estimated completion	30 June 2022
Sites	1 location across United States

Drugs / interventions tested

• Acceptance and Commitment Therapy (ACT)
• Chronic Pain Education

Conditions studied

• HIV/AIDS — all drugs for HIV/AIDS →
• Chronic Pain — all drugs for Chronic Pain →

Sponsor

University of California, San Diego

Who can join

50 and older, any sex, with HIV/AIDS or Chronic Pain. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Change in Chronic Pain Acceptance Questionnaire (CPAQ) Week 0 to Week 6 Primary · 6 weeks

Change in Chronic Pain Acceptance Questionnaire or CPAQ from study entry to end of intervention. This scale measures acceptance of chronic pain and measures two factors: activity engagement (pursuit of life activities regardless of pain) and pain willingness (recognition that avoidance and control are often unworkable methods of adapting to chronic pain). A total of 20 items represents these two factors and the items are rated on a 7-point scale from 0 (never true) to 6 (always true). Scoring the CPAQ requires adding the summed items for activity engagement and pain willingness for a total sco

Group	Value	95% CI
Acceptance and Commitment Therapy (ACT)	5	2.5 – 7
Education Control	13	6 – 29

Change in Chronic Pain Acceptance Questionnaire Week 0 to Week 3 Secondary · 3 weeks

Change in Chronic Pain Acceptance Questionnaire or CPAQ from study entry to end of intervention. This scale measures acceptance of chronic pain and measures two factors: activity engagement (pursuit of life activities regardless of pain) and pain willingness (recognition that avoidance and control are often unworkable methods of adapting to chronic pain). A total of 20 items represents these two factors and the items are rated on a 7-point scale from 0 (never true) to 6 (always true). Scoring the CPAQ requires adding the summed items for activity engagement and pain willingness for a total sco

Group	Value	95% CI
Acceptance and Commitment Therapy (ACT)	5.5	4.75 – 6.25
Education Control	13	5 – 21

Brief Pain Inventory Interference Subscale Secondary · 6 weeks

Change in the Brief Pain Inventory (BPI) Interference subscale from week 0 to 6. The BPI allows persons to rate the severity of their pain (pain severity subscale) and the degree to which their pain interferes with feeling and function (interference subscale). The severity scale assess pain at its "worst, least, average and now". These 4 items are ranked from 0 (no pain) to 10 (pain as bad as you can imagine). Most commonly single items of "worst" and "average" are used to represent severity. A composite of the four items (mean severity score) is often also presented. Pain interference has 7 i

Group	Value	95% CI
Acceptance and Commitment Therapy (ACT)	-1.71	-2.57 – -0.86
Education Control	-0.14	-1.21 – 0.21

Change in Pain Education Score Secondary · Week 0 to Week 6

Difference from Week 0 to 6 in proportion of pain knowledge questions answered correctly.

Group	Value	95% CI
Acceptance and Commitment Therapy (ACT)	0.05	-0.075 – 0.175
Education Control	0.1	0.1 – 0.2

Sponsor's own description

Chronic pain impacts a large proportion of aging people living with HIV (aPLWH) and involves factors directly related to HIV (neurotoxicity) and psychosocial co-morbidities common in aPLWH (i.e. social isolation and loneliness). The investigators hypothesize that novel interventions that acknowledge these psychosocial co-morbidities may improve the efficacy of chronic pain management and minimize the use of potentially dangerous medications. This grant proposes to adapt and pilot a pain psychotherapy approach using group acceptance and commitment therapy (ACT) in aPLWH with chronic pain.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.