NCT03698149: BRAVO

ECoG BMI for Motor and Speech Control

Recruiting now NA Last updated 11 June 2025

What this trial tests

NA trial testing PMT/Blackrock Combination Device in ALS in 3 participants. Currently enrolling.

Timeline

9 November 2018

Primary endpoint
28 February 2026

15 August 2030

Quick facts

Lead sponsor	Karunesh Ganguly
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	device feasibility
Enrollment	3
Start date	9 November 2018
Primary completion	28 February 2026
Estimated completion	15 August 2030
Sites	1 location across United States

Drugs / interventions tested

• PMT/Blackrock Combination Device

Conditions studied

• ALS — all drugs for ALS →
• SCI - Spinal Cord Injury — all drugs for SCI - Spinal Cord Injury →
• Stroke — all drugs for Stroke →
• Multiple Sclerosis — all drugs for Multiple Sclerosis →

Sponsor

Karunesh Ganguly

Who can join

21 and older, any sex, with ALS or SCI - Spinal Cord Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria.
   Moses DA, Metzger SL, Liu JR, Anumanchipalli GK, et al · · 2021 · cited 327× · PMID 34260835 · DOI 10.1056/nejmoa2027540
2. A high-performance neuroprosthesis for speech decoding and avatar control.
   Metzger SL, Littlejohn KT, Silva AB, Moses DA, et al · · 2023 · cited 290× · PMID 37612505 · DOI 10.1038/s41586-023-06443-4
3. Generalizable spelling using a speech neuroprosthesis in an individual with severe limb and vocal paralysis.
   Metzger SL, Liu JR, Moses DA, Dougherty ME, et al · · 2022 · cited 97× · PMID 36347863 · DOI 10.1038/s41467-022-33611-3
4. Brain-Computer Interfaces in Neurorecovery and Neurorehabilitation.
   Young MJ, Lin DJ, Hochberg LR. · · 2021 · cited 35× · PMID 33742433 · DOI 10.1055/s-0041-1725137
5. Use of Invasive Brain-Computer Interfaces in Pediatric Neurosurgery: Technical and Ethical Considerations.
   Bergeron D, Iorio-Morin C, Bonizzato M, Lajoie G, et al · · 2023 · cited 26× · PMID 37116888 · DOI 10.1177/08830738231167736
6. A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages.
   Silva AB, Liu JR, Metzger SL, Bhaya-Grossman I, et al · · 2024 · cited 23× · PMID 38769157 · DOI 10.1038/s41551-024-01207-5
7. Sampling representational plasticity of simple imagined movements across days enables long-term neuroprosthetic control.
   Natraj N, Seko S, Abiri R, Miao R, et al · · 2025 · cited 18× · PMID 40054446 · DOI 10.1016/j.cell.2025.02.001
8. Toward the Clinical Translation of Implantable Brain-Computer Interfaces for Motor Impairment: Research Trends and Outcome Measures.
   Dohle E, Swanson E, Jovanovic L, Yusuf S, et al · · 2025 · cited 3× · PMID 40697162 · DOI 10.1002/advs.202501912