Last reviewed · How we verify
More Relaxation by Deep Breath on Methacholine (SouProvocBro)
Deep inhalation (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation. The hypothesis tested was that DI induces more relaxation in methacholine induced bronchoconstriction-solely determined by the smooth muscle contraction-than in exercise induced bronchoconstriction, which is contributed to by both smooth muscle contraction and airway wall inflammation.
Details
| Lead sponsor | Central Hospital, Nancy, France |
|---|---|
| Status | COMPLETED |
| Enrolment | 78 |
| Start date | Sat Jul 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Sep 30 2016 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Childhood Asthma
Interventions
- bronchial provocation test