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More Relaxation by Deep Breath on Methacholine (SouProvocBro)

NCT03696602 COMPLETED

Deep inhalation (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation. The hypothesis tested was that DI induces more relaxation in methacholine induced bronchoconstriction-solely determined by the smooth muscle contraction-than in exercise induced bronchoconstriction, which is contributed to by both smooth muscle contraction and airway wall inflammation.

Details

Lead sponsorCentral Hospital, Nancy, France
StatusCOMPLETED
Enrolment78
Start dateSat Jul 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time)
CompletionFri Sep 30 2016 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Interventions