NCT03696433

Visualizing Vascular Mechanisms of Salt Sensitivity

Completed NA Results posted Last updated 15 January 2025

What this trial tests

NA trial testing Low-salt diet in Obesity in 19 participants. Completed in 4 November 2022.

Timeline

1 February 2019

Primary endpoint
4 November 2022

4 November 2022

Quick facts

Lead sponsor	Vanderbilt University Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	basic science
Enrollment	19
Start date	1 February 2019
Primary completion	4 November 2022
Estimated completion	4 November 2022
Sites	1 location across United States

Drugs / interventions tested

• Low-salt diet
• High-salt diet

Conditions studied

• Obesity — all drugs for Obesity →
• Cardiovascular Risk Factor — all drugs for Cardiovascular Risk Factor →
• Salt; Excess — all drugs for Salt; Excess →

Sponsor

Vanderbilt University Medical Center

Who can join

Adults 18 to 55, any sex, with Obesity or Cardiovascular Risk Factor. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Mean Arterial Blood Pressure Following High-salt Diet and Low-salt Diet Primary · Following completion of all dietary supplements and washout, in no less than 21 days.

Mean arterial pressure following high-salt diet and low-salt diet

Group	Value	95% CI
Low Salt Diet	83.3	± 21.4
High Salt Diet	89.5	± 9.55

Adverse events — posted to ClinicalTrials.gov

Time frame: Baseline up to 8 weeks. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Low Salt Diet

Serious: 0/19 (0%)

Deaths: 0/19

High Salt Diet

Serious: 0/19 (0%)

Deaths: 0/19

Other adverse events (1 terms — click to expand)

Reaction	System	Low Salt Diet	High Salt Diet
episode of syncope	Metabolism and nutrition disorders	—	—

Data from ClinicalTrials.gov NCT03696433 adverse events section.

Sponsor's own description

This study aims to assess the salt sensitive blood pressure response to dietary salt load compared with radiological markers of salt handling.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.