NCT03696082 (CogEx) is a NA clinical trial of Aerobic Activity in Cognition Disorders, sponsored by University of Pittsburgh.

Who is sponsoring NCT03696082?

NCT03696082 is sponsored by University of Pittsburgh.

What drugs are being tested in NCT03696082?

Interventions in NCT03696082: Aerobic Activity, Resistance Training, Yoga, Health Education.

What condition does NCT03696082 study?

NCT03696082 studies Cognition Disorders, Brain Pathology, Physical Disability, Physical Activity, Aging.

Is NCT03696082 still recruiting?

NCT03696082 is currently terminated. Last updated 22 March 2023.

Last reviewed 2023-03-22 · How we verify

NCT03696082: CogEx

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Precision Rehabilitation Approach to Counteract Age-Related Cognitive Declines

Terminated NA Last updated 22 March 2023

What this trial tests

NA trial testing Aerobic Activity in Cognition Disorders in 78 participants. Terminated before completion.

Timeline

1 September 2018

Primary endpoint
31 January 2022

31 December 2022

Quick facts

Lead sponsor	University of Pittsburgh
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	single
Primary purpose	other
Enrollment	78
Start date	1 September 2018
Primary completion	31 January 2022
Estimated completion	31 December 2022
Sites	1 location across United States

Drugs / interventions tested

Aerobic Activity
Resistance Training
Yoga
Health Education

Conditions studied

Cognition Disorders — all drugs for Cognition Disorders →
Brain Pathology — all drugs for Brain Pathology →
Physical Disability — all drugs for Physical Disability →
Physical Activity — all drugs for Physical Activity →

Sponsor

University of Pittsburgh

Who can join

Adults 65 to 80, any sex, with Cognition Disorders or Brain Pathology. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study examines the behavioral, molecular, and structural biomarkers of brain health that will allow for the stratification of individuals according to their "cognitive signature" and function. This study will randomize older adults into one of four interventions for a period of 12 months: 1) Aerobic Exercise, 2) Resistance Exercise, 3) Yoga Exercise, 4) Health Education (involves stretching and range of motion activities). This aims of this study will examine whether and how these different types of training interventions exert effects cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Current understanding and prospects for targeting neurogenesis in the treatment of cognitive impairment.
Liu Y, Ding X, Jia S, Gu X. · · 2026 · cited 10× · PMID 39820472 · DOI 10.4103/nrr.nrr-d-24-00802

Verify or expand the search:

Other recruiting trials for Cognition Disorders

Currently open trials in the same condition.

NCT07526740 — Brain Stimulation and Cognitive Training for MCI · NA · recruiting
NCT06836440 — Impact of Glasses for Vision Problems on Cognitive Function in Rural Older Adults · NA · recruiting

Other University of Pittsburgh trials

Trials by the same sponsor.

NCT05601206 — Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · NA · not yet recruiting
NCT06652815 — Cognition, Metacognition, and Stigma in Patients With Suicidal Ideation · not yet recruiting
NCT06474286 — Prucalopride for Cognitive Functioning in Schizophrenia · NA · not yet recruiting
NCT06488469 — Behavioural Problems and Cognition in Children With Hypoglycemia Unawareness in Type-1 Diabetes Mellitus · NA · not yet recruiting
NCT06652802 — Effectiveness of Nurse-Conducted Brief Intervention (NCBI) Supplemented With Mobile for Preventing Alcohol Use Disorders · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03696082 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pittsburgh
Last refreshed: 22 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03696082.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing