Last reviewed · How we verify
NCT03694691
Developing Viability Index for Machine Perfused Livers
NA trial testing Liver Biopsy in Liver Cirrhoses in 60 participants. Currently enrolling.
1 December 2028
Quick facts
| Lead sponsor | Massachusetts General Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 60 |
| Start date | 1 October 2018 |
| Primary completion | 1 December 2028 |
| Estimated completion | 1 June 2030 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Liver Biopsy — full drug profile →
Conditions studied
- Liver Cirrhoses — all drugs for Liver Cirrhoses →
Sponsor
Massachusetts General Hospital
Who can join
Adults 18 to 75, any sex, with Liver Cirrhoses. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable. However, there are no validated metrics to determine transplantability after machine perfusion. This study involves collecting biopsies from transplanted livers before and after implantation to correlate metabolite and gene expression with post-transplant function. This data will help develop a viability index for machine perfused livers.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03694691
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Liver Biopsy
Trials testing the same drug.
- NCT06797193 — Ultrasound With Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension · NA · recruiting
- NCT04677101 — Liquid Biopsy for NASH and Liver Fibrosis · completed
- NCT06499675 — Prevalence of Steatosis and Steatohepatitis in Patients Undergoing Bariatric Surgery; a Biopsy-based Study · completed
- NCT03990623 — CT Perfusion Scans in Detecting Changes in Blood Flow to the Liver After Portal Vein Embolization · NA · unknown
- NCT04750031 — Pain Scores and Complications do Not Differ at Three Recovery Position After Liver Biopsy · unknown
Other recruiting trials for Liver Cirrhoses
Currently open trials in the same condition.
- NCT07058155 — Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease · Phase 4 · recruiting
- NCT06756009 — Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters · recruiting
- NCT04525833 — Liver Disease and Other Systemic Diseases · recruiting
- NCT04326946 — International Alfapump Cohort Study · active not recruiting
- NCT04140578 — Antibiotic Prophylaxis in Patients Undergoing GVO · Phase 4 · recruiting
Other Massachusetts General Hospital trials
Trials by the same sponsor.
- NCT03585946 — Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis · withdrawn
- NCT07214831 — A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerg · NA · not yet recruiting
- NCT06686901 — A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior · NA · not yet recruiting
- NCT05854212 — Behavioral Economics to Implement Nutrition Ranking in Food Pantries · NA · not yet recruiting
- NCT07323446 — The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation · EARLY_PHASE1 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03694691 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
- Last refreshed: 3 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03694691.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing