NCT03692975: Micro-MS

MRI Hippocampal Microstructure and Episodic Memory in Early Multiple Sclerosis

Completed NA Last updated 8 March 2023

What this trial tests

NA trial testing Clinical assessment in Multiple Sclerosis in 84 participants. Completed in 24 February 2023.

Timeline

12 February 2019

Primary endpoint
24 February 2023

24 February 2023

Quick facts

Lead sponsor	University Hospital, Bordeaux
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	84
Start date	12 February 2019
Primary completion	24 February 2023
Estimated completion	24 February 2023
Sites	1 location across France

Drugs / interventions tested

• Clinical assessment — full drug profile →
• Neuropsychological evaluation
• Psychological evaluation
• MRI Evaluation

Conditions studied

• Multiple Sclerosis — all drugs for Multiple Sclerosis →

Sponsor

University Hospital, Bordeaux

Who can join

Adults 18 to 60, any sex, with Multiple Sclerosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Clinically isolated syndrome (CIS) can evolve into multiple sclerosis. In CIS patients, episodic memory is frequently impaired. Memory disorders could be preceded by microstructural abnormalities without visible atrophy in hippocampus. A recent MRI imaging of diffusion called NODDI (Neurite Orientation Dispersion and Density Imaging) can measure specifically microstructural abnormalities and map the axons in the white matter (WM) and dendrites in the grey matter (GM). The aim of this study is to evaluate microstructural abnormalities in the dentate gyrus of the hippocampus in CIS patients compared to controls.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.